*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GR8575000
CHEMICAL NAME : Cumene
CAS REGISTRY NUMBER : 98-82-8
LAST UPDATED : 199712
DATA ITEMS CITED : 43
MOLECULAR FORMULA : C9-H12
MOLECULAR WEIGHT : 120.21
WISWESSER LINE NOTATION : 1Y1&R
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzene, isopropyl
* Benzene, (1-methylethyl)-
* Cumeen
* Cumene
* Cumol
* 2-Fenilpropano
* 2-Fenyl-propaan
* Isopropylbenzeen
* Isopropilbenzene
* Isopropyl benzene
* Isopropylbenzol
* Isopropyl-benzol
* (1-Methylethyl)benzene
* 2-Phenylpropane
* Propane, 2-phenyl
* RCRA waste number U055
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 10 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,119,1951
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/24H
REACTION SEVERITY : Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,33,1986
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 86 mg
REACTION SEVERITY : Mild
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 14,387,1956
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,33,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 200 ppm
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - antipsychotic
Behavioral - irritability
REFERENCE :
TGNCDL "Handbook of Organic Industrial Solvents," 2nd ed., Chicago, National
Assoc. of Mutual Casualty Companies, 1961 Volume(issue)/page/year: 2,39,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1400 mg/kg
TOXIC EFFECTS :
Gastrointestinal - gastritis
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 14,387,1956
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,119,1951
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 12750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 36(9),18,1971
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 10 gm/m3/7H
TOXIC EFFECTS :
Liver - multiple effects
Kidney, Ureter, Bladder - changes in both tubules and glomeruli
Blood - changes in spleen
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,264,1944
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 12300 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,119,1951
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1200 ppm/6H/13W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - changes in motor activity (specific assay)
Blood - pigmented or nucleated red blood cells
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0522342
*** REVIEWS ***
ACGIH TLV-TWA 246 mg/m3 (50 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 50 ppm (245 mg/m3) (skin)
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,14,1973
OSHA PEL (Gen Indu):8H TWA 50 ppm (245 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 50 ppm (245 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 50 ppm (245 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 50 ppm (245 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 50 ppm (245 mg/m3);Skin JAN 1993
OEL-AUSTRIA:TWA 50 ppm (245 mg/m3);Skin JAN 1993
OEL-BELGIUM:TWA 50 ppm (246 mg/m3);Skin JAN 1993
OEL-DENMARK:TWA 50 ppm (245 mg/m3);Skin JAN 1993
OEL-FINLAND:TWA 50 ppm (245 mg/m3);STEL 75 ppm (370 mg/m3);Skin JAN 1993
OEL-FRANCE:TWA 50 ppm (245 mg/m3);Skin JAN 1993
OEL-GERMANY:TWA 50 ppm (245 mg/m3);Skin JAN 1993
OEL-HUNGARY:TWA 80 mg/m3;STEL 100 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 50 ppm (245 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 50 ppm (245 mg/m3);Skin JAN 1993
OEL-RUSSIA:STEL 50 mg/m3 JAN 1993
OEL-SWEDEN:TWA 25 ppm (120 mg/m3);STEL 35 ppm (170 mg/m3);Skin JAN 1993
OEL-SWITZERLAND:TWA 50 ppm (245 mg/m3);Skin JAN 1993
OEL-UNITED KINGDOM:TWA 50 ppm (245 mg/m3);STEL 75 ppm;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CUMENE-air:10H TWA 50 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 20850
No. of Facilities: 24 (estimated)
No. of Industries: 2
No. of Occupations: 8
No. of Employees: 669 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 20850
No. of Facilities: 1199 (estimated)
No. of Industries: 15
No. of Occupations: 24
No. of Employees: 14268 (estimated)
No. of Female Employees: 2760 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S
cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Hydrocarbons, aromatic, 1501
NTP Carcinogenesis studies; selected, October 1997
*** END OF RECORD ***