*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GP1339000
CHEMICAL NAME           : p-Cresol,
                          alpha-(p-hydroxyphenyl)-alpha-(2-methylcyclohexyliden
                          e)-, diacetate
CAS REGISTRY NUMBER     : 21327-74-2
BEILSTEIN REFERENCE NO. : 2676082
LAST UPDATED            : 199612
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C24-H26-O4
MOLECULAR WEIGHT        : 378.50
WISWESSER LINE NOTATION : L6YTJ AUYR DOV1&R DOV1& B1
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 4-((4-(Acetyloxy)phenyl)(2-methylcyclohexylidene)methyl)phenol acetate
   * Bis(p-acetoxyphenyl)-2-methylcyclohexylidenemethane
   * F 6103
   * alpha-(p-Hydroxyphenyl)-alpha-(2-methylcyclohexylidene)-p-cresol  
   diacetate
   * Phenol, 4-((4-(acetyloxy)phenyl)(2-methylcyclohexylidene)methyl)-,  
   acetate
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2 mg/kg
SEX/DURATION            : female 1-2 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   APTSAI Acta Pharmacologica et Toxicologica, Supplementun.  (Munksgaard
   International Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  No.1- 1947- 
   Volume(issue)/page/year: 26(1),1,1968
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5 mg/kg
SEX/DURATION            : female 5 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 14,487,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1500 ug/kg
SEX/DURATION            : female 3 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 5,473,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3 mg/kg
SEX/DURATION            : female 6 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   APTSAI Acta Pharmacologica et Toxicologica, Supplementun.  (Munksgaard
   International Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  No.1- 1947- 
   Volume(issue)/page/year: 26(1),1,1968
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 500 ug/kg
SEX/DURATION            : female 3-4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   APTSAI Acta Pharmacologica et Toxicologica, Supplementun.  (Munksgaard
   International Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  No.1- 1947- 
   Volume(issue)/page/year: 26(1),1,1968
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 7200 ug/kg
SEX/DURATION            : female 10-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   APTSAI Acta Pharmacologica et Toxicologica, Supplementun.  (Munksgaard
   International Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  No.1- 1947- 
   Volume(issue)/page/year: 26(1),1,1968
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 28800 ug/kg
SEX/DURATION            : female 19-27 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   APTSAI Acta Pharmacologica et Toxicologica, Supplementun.  (Munksgaard
   International Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  No.1- 1947- 
   Volume(issue)/page/year: 26(1),1,1968
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 115 mg/kg
SEX/DURATION            : female 10-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   APTSAI Acta Pharmacologica et Toxicologica, Supplementun.  (Munksgaard
   International Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  No.1- 1947- 
   Volume(issue)/page/year: 26(1),1,1968
 
                            *** END OF RECORD ***