*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GT9330000
CHEMICAL NAME           : 7,20-Cycloatidane-11,15-diol,
                          16,17-didehydro-21-ethyl-4-methyl-,
                          (11-beta,15-beta)-
CAS REGISTRY NUMBER     : 26166-37-0
LAST UPDATED            : 198405
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C22-H33-N-O2
MOLECULAR WEIGHT        : 343.56
SYNONYMS/TRADE NAMES :
   * Denudatine
   * 16,17-Didehydro-21-ethyl-4-methyl-7,20-cycloatidane-11-beta,15-beta-diol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Cardiac - change in rate
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   3,104,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 290 mg/kg
TOXIC EFFECTS :
   Cardiac - arrhythmias (including changes in conduction)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   3,104,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 128 mg/kg
TOXIC EFFECTS :
   Cardiac - arrhythmias (including changes in conduction)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   3,104,1982
 
                            *** END OF RECORD ***