*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GP1755000
CHEMICAL NAME           : p-Cresol, 2-methoxy-
CAS REGISTRY NUMBER     : 93-51-6
BEILSTEIN REFERENCE NO. : 1862340
REFERENCE               : 4-06-00-05878 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C8-H10-O2
MOLECULAR WEIGHT        : 138.18
WISWESSER LINE NOTATION : QR D1 BO1
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * p-Creosol
   * Homoguaiacol
   * 4-Hydroxy-3-methoxy-1-methylbenzene
   * 4-Hydroxy-3-methoxytoluene
   * Kreosol
   * 2-Methoxy-p-cresol
   * 3-Methoxy-4-hydroxytoluene
   * 2-Methoxy-4-methylphenol
   * p-Methylguaiacol
   * 4-Methylguaiacol
   * Phenol, 2-methoxy-4-methyl-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 740 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
REFERENCE :
   FMCRAW Folia Medica Cracoviensia.  (Ars Polona, POB 1001, 00-068 Warsaw,
   Poland)  V.1-    1959-  Volume(issue)/page/year: 32,309,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 76 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 164,30,1966
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 30196 mg/kg/40D-I
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   FMCRAW Folia Medica Cracoviensia.  (Ars Polona, POB 1001, 00-068 Warsaw,
   Poland)  V.1-    1959-  Volume(issue)/page/year: 32,309,1991
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 500 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 206,17,1988

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - A1512
       No. of Facilities: 14 (estimated)
       No. of Industries: 2
       No. of Occupations: 6
       No. of Employees: 1639 (estimated)
       No. of Female Employees: 276 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***