*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GU6780000
CHEMICAL NAME           : Cyclohexaneacetic acid, alpha-phenyl-,
                          2-(diethylamino)ethyl ester
CAS REGISTRY NUMBER     : 1679-76-1
BEILSTEIN REFERENCE NO. : 2059173
REFERENCE               : 4-09-00-02145 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C20-H31-N-O2
MOLECULAR WEIGHT        : 317.52
WISWESSER LINE NOTATION : L6TJ AYR&VO2N2&2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Adiphenine H
   * Benzeneacetic acid, alpha-cyclohexyl-, 2-(diethylamino)ethyl ester
   * Cycloadiphene
   * Drofenine
   * Hexahydroadiphenine
   * Trasentine-6H
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1600 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1600 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 37 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AJDDAL American Journal of Digestive Diseases.  (New York, NY)  V.5-22,
   1938-55; New series: V.1-23, 1956-78.  For publisher information, see
   DDSCDJ.  Volume(issue)/page/year: 18,241,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle weakness
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 14,559,1959
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
                            *** END OF RECORD ***