*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GW4570000
CHEMICAL NAME           : 3-Cyclohexene-1-carboxylic acid, 2-phenyl-,
                          2-dimethylaminoethyl ester, hydrochloride
LAST UPDATED            : 199506
DATA ITEMS CITED        : 16
MOLECULAR FORMULA       : C17-H23-N-O2.Cl-H
MOLECULAR WEIGHT        : 309.87
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * beta-Dimethylaminoethyl-2-phenyltetrahydrobenzoate hydrochloride
   * 2-Phenyl-3-cyclohexene-1-carboxylic acid 2-dimethylaminoethyl ester  
   hydrochloride
   * S 187
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : >200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : >200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : >267 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 267 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 27 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : >50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPNAH Acta Physiologica et Pharmacologica Neerlandica.  (Amsterdam,
   Netherlands)  V.1-15, 1950-69. For publisher information, see EJPHAZ.
   Volume(issue)/page/year: 1,4,1950
 
                            *** END OF RECORD ***