*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GY1925000
CHEMICAL NAME : Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-
1,11-dione, 2,3,6a,9a-tetrahydro- 4-methoxy-
CAS REGISTRY NUMBER : 1162-65-8
OTHER CAS REGISTRY NOS. : 11003-08-0
BEILSTEIN REFERENCE NO. : 1269174
LAST UPDATED : 199806
DATA ITEMS CITED : 276
MOLECULAR FORMULA : C17-H12-O6
MOLECULAR WEIGHT : 312.29
WISWESSER LINE NOTATION : T F5 C6 B655 DOV GV OO QO RUT&&TTJ LO1
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Reproductive Effector
Natural Product
SYNONYMS/TRADE NAMES :
* AFB1
* Aflatoxin B
* Aflatoxin B1
* 6-Methoxydifurocoumarone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
27,2370,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
25,458,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 18,121,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 9 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPYAG Annual Review of Phytopathology. (Annual Reviews, Inc., POB 10139,
Palo Alto, CA 94303) V.1- 1963- Volume(issue)/page/year: 12,303,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 9500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
LSPPAT Life Sciences, Part 1: Physiology and Pharmacology. (New York, NY)
V.9-13, 1970-73. For publisher information, see LIFSAK.
Volume(issue)/page/year: 13,1143,1973
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PAVEAC Pathologia Veterinaria. (Basel, Switzerland) V.1-7, 1964-70. For
publisher information, see VTPHAK. Volume(issue)/page/year: 3,331,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 23,1327,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 2200 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - food intake (animal)
Liver - jaundice, other or unclassified
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
19,169,1971
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 1300 ug/kg
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925-
Volume(issue)/page/year: 49,1023,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 7800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg.,
2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988-
Volume(issue)/page/year: 2,377,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 550 ug/kg
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
29,236,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 550 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg.,
2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988-
Volume(issue)/page/year: 2,377,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 400 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Nutritional and Gross Metabolic - dehydration
REFERENCE :
AJVRAH American Journal of Veterinary Research. (American Veterinary
Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940-
Volume(issue)/page/year: 43,1027,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 23,1327,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - pig
DOSE/DURATION : 620 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPYAG Annual Review of Phytopathology. (Annual Reviews, Inc., POB 10139,
Palo Alto, CA 94303) V.1- 1963- Volume(issue)/page/year: 12,303,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - pig
DOSE/DURATION : 6600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg.,
2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988-
Volume(issue)/page/year: 2,377,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 2 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
19,169,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1400 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Liver - hepatitis (hepatocellular necrosis), zonal
Liver - other changes
REFERENCE :
JPBAA7 Journal of Pathology and Bacteriology. (London, UK) V.1-96,
1892-1968. For publisher information, see JPTLAS. Volume(issue)/page/year:
91,277,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 18,121,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring)
Liver - multiple effects
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
29,236,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 83,53,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 10200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 23,1327,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 6300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 23,1327,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - duck
DOSE/DURATION : 335 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 123,151,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Bird - duck
DOSE/DURATION : 335 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg.,
2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988-
Volume(issue)/page/year: 2,377,1989
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - domestic
DOSE/DURATION : 2 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 225,1062,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - domestic
DOSE/DURATION : 1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 23,1327,1981
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 672 ug/kg/6W-I
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - multiple enzyme effects
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 28,247,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8400 ug/kg/8W-I
TOXIC EFFECTS :
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - multiple enzyme effects
Biochemical - Metabolism (Intermediary) - other
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068
Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 21,207,1988
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 9 mg/kg/6W-I
TOXIC EFFECTS :
Blood - change in clotting factors
Blood - changes in erythrocyte (RBC) count
Blood - changes in leukocyte (WBC) count
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 13,569,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4900 ug/kg/2W-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count
Blood - changes in leukocyte (WBC) count
Immunological Including Allergic - decrease in cellular immune response
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 43,123,1987
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 9800 ug/kg/4W-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count
Immunological Including Allergic - decrease in cellular immune response
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,6,1985
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 250 ug/kg/5D-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
Biochemical - Effect on specific coenzyme - proportion of isoenzymes
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 108,39,1996
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - pig
DOSE/DURATION : 974 ug/kg/15W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
15,393,1969
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 2100 ug/kg/6W-I
TOXIC EFFECTS :
Blood - change in clotting factors
Blood - changes in erythrocyte (RBC) count
Blood - changes in leukocyte (WBC) count
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 13,569,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 2940 ug/kg/3W-C
TOXIC EFFECTS :
Liver - other changes
Liver - changes in liver weight
Biochemical - Metabolism (Intermediary) - Plasma proteins not involving
coagulation
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 134,683,1970
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - quail
DOSE/DURATION : 672 ug/kg/6W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Biochemical - Metabolism (Intermediary) - Plasma proteins not involving
coagulation
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 134,683,1970
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - turkey
DOSE/DURATION : 1008 ug/kg/3W-C
TOXIC EFFECTS :
Liver - other changes
Liver - changes in liver weight
Biochemical - Metabolism (Intermediary) - Plasma proteins not involving
coagulation
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 134,683,1970
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 380 ug/kg/68W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
27,2370,1967
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2 mg/kg
female 18-21 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Endocrine - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 64,1349,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6 mg/kg/8W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
31,1936,1971
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 800 ug/kg/10W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Tumorigenic - tumors at site of application
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
35,3811,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8 mg/kg
female 15 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Skin and Appendages - tumors
REFERENCE :
IARCCD IARC Scientific Publications. (Geneva, Switzerland) No.1-26,
1971-78. For publisher information, see IAPUDO. Volume(issue)/page/year:
4,100,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 150 mg/kg/6W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
82,19,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 6 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 5,385,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 30 mg/kg
female 15-22 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Skin and Appendages - tumors
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.41- 1956- Volume(issue)/page/year: 82,1687,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 168 mg/kg/6Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
57,67,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Multiple routes
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 20 mg/kg/4Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
57,67,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 60 mg/kg/6W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 68,271,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - duck
DOSE/DURATION : 1260 ug/kg/60W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 208,308,1965
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 3 mg/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
NUCADQ Nutrition and Cancer. (Franklin Institute Press, POB 2266,
Phildelphia, PA 19103) V.1- 1978- Volume(issue)/page/year: 11,55,1988
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 120 mg/kg/74W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 34,827,1975
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15 mg/kg/6W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 6,135,1968
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2000 ug/kg/4W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
31,1936,1971
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1600 ug/kg/20W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
31,1936,1971
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8400 ug/kg/20W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 34,1069,1978
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8 mg/kg/20W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
29,2206,1969
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2205 ug/kg/21W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
29,1045,1969
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 18 mg/kg/43W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - angiosarcoma
Gastrointestinal - colon tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
55,107,1975
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1323 ug/kg/63W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
47,1913,1987
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1500 ug/kg/7W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
35,2469,1975
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 19 mg/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
1957- Volume(issue)/page/year: 28,35,1981
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 5 mg/kg
SEX/DURATION : female 16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific
Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- Volume(issue)/page/year:
47,242,1966
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 675 ug/kg
SEX/DURATION : female 1-22 day(s) after conception
lactating female 5 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - postpartum
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 10,307,1972
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 8100 ug/kg
SEX/DURATION : female 1-22 day(s) after conception
lactating female 5 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 10,307,1972
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 2 mg/kg
SEX/DURATION : female 18-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 64,1349,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 10 mg/kg
SEX/DURATION : female 17-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New
York, NY 10003) V.15- 1970- Volume(issue)/page/year: 33,283,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 960 ug/kg
SEX/DURATION : male 15 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 17,9,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 1200 ug/kg
SEX/DURATION : female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 18(Suppl
1),113,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intratesticular
SPECIES OBSERVED : Rodent - rat
DOSE : 200 ug/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 5,263,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 4 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
AVSCA7 Acta Veterinaria Scandinavica. (Danske Dyrlargeforening, Alhambravej
15, DK-1826 Copenhagen V, Denmark) V.1- 1959- Volume(issue)/page/year:
22,524,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 5 mg/kg
SEX/DURATION : female 7-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 215,638,1967
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 64 mg/kg
SEX/DURATION : female 6-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 24(1),25A,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 32 mg/kg
SEX/DURATION : female 10-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 24(1),25A,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 64 mg/kg
SEX/DURATION : female 10-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 24(1),25A,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - hamster
DOSE : 4 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 215,638,1967
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - hamster
DOSE : 4 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
JCVPAR Journal of Comparative Pathology. (Academic Press, Inc., 1 E. First
St., Duluth, MN 55802) V.75- 1965- Volume(issue)/page/year: 90,339,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - hamster
DOSE : 4 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of
Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
Volume(issue)/page/year: 163,801,1969
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 700 ng/plate
REFERENCE :
AEMIDF Applied and Environmental Microbiology. (American Soc. for
Microbiology, 1913 I St., NW, Washington, DC 20006) V.31- 1976-
Volume(issue)/page/year: 35,659,1978
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10 ng/plate
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
22,355,1984
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 192,239,1987
TYPE OF TEST : DNA adduct
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 160 nmol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 76,1343,1979
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 1 ug/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,121,1979
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 5 pmol/tube
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 79,5971,1982
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 200 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 130,97,1984
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 2 ug/well
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,429,1981
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 10 ng/tube
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,1,1981
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 10 mg/L
REFERENCE :
CMMUAO Chemical Mutagens. Principles and Methods for Their Detection.
(Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1971-
Volume(issue)/page/year: 9,165,1984
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 600 ng/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,1,1982
TYPE OF TEST : DNA damage
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 6 gm/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 225,68,1970
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 9790 ug/L
REFERENCE :
JMIMDQ Journal of Microbiological Methods. (Elsevier Science Pub. B.V., POB
211, 1000 AE Amsterdam, Netherlands) V.1- 1983- Volume(issue)/page/year:
3,181,1985
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 640 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 106,195,1982
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 40 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 107,23,1983
TYPE OF TEST : DNA adduct
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 220 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
35,382,1975
TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 40 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 107,23,1983
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 10 ug/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 2,417,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 500 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,235,1996
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 5 mg/L
REFERENCE :
APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For
publisher information, see AEMIDF. Volume(issue)/page/year: 20,782,1970
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 160 umol/L/3H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 120,233,1983
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 32 nmol/L
REFERENCE :
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301
N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
Volume(issue)/page/year: 1(3),133,1985
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 50 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
38,2608,1978
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Mold - Neurospora crassa
DOSE/DURATION : 130 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
32,1890,1972
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Mold - Neurospora crassa
DOSE/DURATION : 440 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 37,27,1976
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 270 umol/L
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
Volume(issue)/page/year: 83,14,1978
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 530 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 45,309,1977
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 125 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 175,223,1986
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Fish - not otherwise specified
DOSE/DURATION : 10 mg/kg
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
Volume(issue)/page/year: 47,147,1986
TYPE OF TEST : DNA adduct
TEST SYSTEM : Fish - not otherwise specified Liver
DOSE/DURATION : 60 ug/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 3,511,1982
TYPE OF TEST : DNA adduct
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Fish - not otherwise specified
DOSE/DURATION : 5 ug/kg
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 68,623,1982
TYPE OF TEST : DNA adduct
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Fish - salmon
DOSE/DURATION : 5 ug/kg
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 68,623,1982
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Fish - salmon Cells - not otherwise specified
DOSE/DURATION : 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,153,1983
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Fish - not otherwise specified Ovary
DOSE/DURATION : 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,153,1983
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Fish - not otherwise specified Cells - not otherwise
specified
DOSE/DURATION : 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,153,1983
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Fish - not otherwise specified Liver
DOSE/DURATION : 100 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
44,1120,1984
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Fish - not otherwise specified Liver
DOSE/DURATION : 10 umol/L
REFERENCE :
NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing
Office, Supt. of Documents, Washington, DC 20402) No.1- 1959-
Volume(issue)/page/year: 65,163,1984
TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 2 ug
REFERENCE :
MYCPAH Mycopathologia. (Kluwer Academic Pub. Group, Distribution Centre,
POB 322, 3300 AH Dordrecht, Netherlands) V.1- 1938-
Volume(issue)/page/year: 88,23,1984
TYPE OF TEST : Micronucleus test
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 100 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 91,63,1981
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 100 ug/L
REFERENCE :
42GEA8 "Environmental Carcinogenesis: Occurrence, Risk Evaluation and
Mechanisms, Proceedings of the International Conference, 1979," Emmelot, P.,
and E. Kriek, eds., New York, Elsevier Science Pub. Co. Inc., 1979
Volume(issue)/page/year: -,97,1979
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 2500 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
41,5096,1981
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 10 mg/L
REFERENCE :
ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher
information, see ICDBEO. Volume(issue)/page/year: 17,719,1981
TYPE OF TEST : DNA adduct
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 1 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 3,1345,1982
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Liver
DOSE/DURATION : 2 ppm/3H
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 214,814,1967
TYPE OF TEST : DNA adduct
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 1 umol/L
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
1,3,1980
TYPE OF TEST : DNA damage
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 32 mg/L/24H
REFERENCE :
JJEMAG Japanese Journal of Experimental Medicine. (Kinokuniya Book-Stores
of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581
Webster St., San Francisco, CA 94115) V.7- 1928- Volume(issue)/page/year:
42,527,1972
TYPE OF TEST : DNA adduct
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 100 ug/L
REFERENCE :
42GEA8 "Environmental Carcinogenesis: Occurrence, Risk Evaluation and
Mechanisms, Proceedings of the International Conference, 1979," Emmelot, P.,
and E. Kriek, eds., New York, Elsevier Science Pub. Co. Inc., 1979
Volume(issue)/page/year: -,97,1979
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 10 umol/L/2H
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
Volume(issue)/page/year: 16,284,1975
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 10 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
38,2621,1978
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 122,377,1983
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Human Liver
DOSE/DURATION : 2 mg/L
REFERENCE :
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific
Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- Volume(issue)/page/year:
49,33,1968
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 50 nmol/L/1H (Continuous)
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 2(1),65,1978
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human Liver
DOSE/DURATION : 2 mg/L
REFERENCE :
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific
Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- Volume(issue)/page/year:
49,33,1968
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human Lung
DOSE/DURATION : 1 ppm
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 208,345,1965
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Human Liver
DOSE/DURATION : 2 mg/L
REFERENCE :
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific
Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- Volume(issue)/page/year:
49,33,1968
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Liver
DOSE/DURATION : 1 umol/L
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
96,360,1988
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 40 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
37,1786,1977
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 300 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7,267,1985
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Mammary gland
DOSE/DURATION : 10 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
20,148,1992
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 100 nmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 5,719,1984
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 1 mg/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year:
30,103,1974
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 100 nmol/L
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 9,21,1978
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lung
DOSE/DURATION : 1 mg/L
REFERENCE :
JAVMA4 Journal of the American Veterinary Medical Association. (American
Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48-
1915- Volume(issue)/page/year: 155,2080,1969
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 60 umol/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring
St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year:
17,3,1975
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 100 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8,423,1986
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 3 mg/L
REFERENCE :
JRARAX Journal of Radiation Research. (Japan Radiation Research Soc., c/o
Tokai Daigaku Igakubu Bunshi Seibutsugaku Kyoshitsu, Tenbodai, Isehara
259-11, Japan) V.1- 1960- Volume(issue)/page/year: 24,356,1983
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 3 nmol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,342,1982
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 2500 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,79,1978
TYPE OF TEST : DNA repair
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 10 nmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
18,107,1991
TYPE OF TEST : DNA adduct
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 20 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 322,61,1994
TYPE OF TEST : Morphological transformation
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 1 mg/kg
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
Volume(issue)/page/year: 76,16,1985
TYPE OF TEST : DNA adduct
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 10900 ng/kg
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
32,249,1980
TYPE OF TEST : Morphological transformation
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 3333 ug/kg/4W (Intermittent)
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
55,579,1975
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 50 ug/L/10W
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
33,606,1973
TYPE OF TEST : DNA adduct
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 1 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 3,1345,1982
TYPE OF TEST : DNA adduct
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 5 mg/kg
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
151,1539,1966
TYPE OF TEST : DNA adduct
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 1 umol/L
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
1,3,1980
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 1 umol/L
REFERENCE :
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301
N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
Volume(issue)/page/year: 6,339,1990
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 1 mg/kg
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 24,65,1983
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 100 nmol/L
REFERENCE :
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert
Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)-
1978- Volume(issue)/page/year: 12,119,1984
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 200 ng/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
42,3659,1982
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 50 ug/kg
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 51,423,1968
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 1 mg/kg
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
Volume(issue)/page/year: 6,74,1970
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 1680 ug/kg/1W (Continuous)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
36,2399,1976
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - rat Fibroblast
DOSE/DURATION : 2500 ug/L
REFERENCE :
FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval Rd.,
London NW1 7DX, UK) V.1- 1955- Volume(issue)/page/year: 32,128,1986
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 500 ug/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 4,1013,1983
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Sperm
DOSE/DURATION : 100 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6,273,1984
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 10 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
45,337,1985
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 100 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 173,217,1986
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 30 mg/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 29,177,1985
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 10 nmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 8,1077,1987
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 12600 ug/kg/3w
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
54,1245,1975
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 750 ug/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
27,2221,1967
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 1 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 242,219,1990
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 1 pmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 8,1077,1987
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 48 nmol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,33,1983
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 130,53,1984
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 15 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 43,255,1977
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 1750 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 95,297,1982
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - mouse Fibroblast
DOSE/DURATION : 500 ug/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 21,92,1980
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - mouse Embryo
DOSE/DURATION : 500 ug/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,105,1982
TYPE OF TEST : DNA adduct
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 24 ug/kg
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
32,249,1980
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 10 mg/L
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
68,619,1977
TYPE OF TEST : DNA adduct
TEST SYSTEM : Rodent - mouse Embryo
DOSE/DURATION : 300 nmol/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 70,135,1983
TYPE OF TEST : DNA adduct
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 20 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 322,61,1994
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - mouse Liver
DOSE/DURATION : 100 nmol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,1,1983
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - mouse Fibroblast
DOSE/DURATION : 500 umol/L
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.1- 1955- Volume(issue)/page/year: 28(11),53,1982
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 20 gm/kg
REFERENCE :
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit
Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
Volume(issue)/page/year: 51,605,1981
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 40 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 46,305,1977
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 20 mg/kg
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
Volume(issue)/page/year: 21,281,1978
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 5 mg/kg
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 7,245,1981
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intravenous
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 20 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 60,329,1979
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 1 mg/L
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
68,619,1977
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 84 ug/kg/6W (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 261,15,1991
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intravenous
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 20 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 60,329,1979
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 100 mg/kg
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
6,1,1986
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 1 mg/L
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
68,619,1977
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 500 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 110,147,1983
TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - mouse Bacteria - Escherichia coli
DOSE/DURATION : 200 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 263,137,1991
TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION : 5 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 263,137,1991
TYPE OF TEST : Micronucleus test
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 203,397,1988
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 630 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 46,27,1977
TYPE OF TEST : Morphological transformation
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - hamster
DOSE/DURATION : 100 mg/kg
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 95,380,1973
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 120 ug/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
37,3508,1977
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Kidney
DOSE/DURATION : 80 ug/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year:
37,873,1978
TYPE OF TEST : DNA adduct
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - hamster
DOSE/DURATION : 400 ug/kg
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
11,123,1975
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 3 umol/L/2H
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
Volume(issue)/page/year: 72,732,1976
TYPE OF TEST : DNA adduct
TEST SYSTEM : Rodent - hamster Cells - not otherwise specified
DOSE/DURATION : 1 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 3,1345,1982
TYPE OF TEST : DNA adduct
TEST SYSTEM : Rodent - hamster Liver
DOSE/DURATION : 2 umol/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 25,118,1984
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - hamster Liver
DOSE/DURATION : 100 nmol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,1,1983
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,153,1983
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 30 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
44,184,1984
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 2 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7,137,1985
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - hamster
DOSE/DURATION : 12500 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 74,164,1980
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 1 mg/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year:
30,103,1974
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 1 umol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
13,89,1981
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Cells - not otherwise specified
DOSE/DURATION : 10 mg/L
REFERENCE :
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St.,
New York, NY 10013) V.1- 1972- Volume(issue)/page/year: 24,433,1981
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - hamster
DOSE/DURATION : 1 ug/kg
REFERENCE :
JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology.
(Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia) V.1-
1957- Volume(issue)/page/year: 28,149,1984
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 45,263,1977
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 100 ug/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 1,759,1980
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 85,289,1981
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Liver
DOSE/DURATION : 30 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 207,69,1988
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Liver
DOSE/DURATION : 30 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 271,79,1992
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 200 umol/L/48H
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 75,2864,1978
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 1 umol/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 21,39,1980
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - guinea pig Cells - not otherwise specified
DOSE/DURATION : 500 ug/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
35,1035,1975
TYPE OF TEST : Morphological transformation
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Primate - monkey
DOSE/DURATION : 700 ug/kg
REFERENCE :
LAINAW Laboratory Investigation. (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21202) V.1- 1952- Volume(issue)/page/year:
30,267,1974
TYPE OF TEST : DNA adduct
TEST SYSTEM : Primate - monkey Cells - not otherwise specified
DOSE/DURATION : 1 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 3,1345,1982
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Primate - monkey Liver
DOSE/DURATION : 50 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 206,91,1988
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Primate - monkey Kidney
DOSE/DURATION : 10 ug/L
REFERENCE :
SAMJAF South African Medical Journal. (Medical Assoc. of South Africa,
Secy., P.O. Box 643, Cape Town, S. Africa) V.6- 1932-
Volume(issue)/page/year: 49,273,1975
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Mammal - domestic Cells - not otherwise specified
DOSE/DURATION : 10 mg/L
REFERENCE :
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New
York, NY 10003) V.1- 1981- Volume(issue)/page/year: 24,157,1991
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Primate - monkey Kidney
DOSE/DURATION : 2 mg/L
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
48,1647,1972
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Primate - monkey Kidney
DOSE/DURATION : 500 ug/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
18,267,1977
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Primate - monkey Kidney
DOSE/DURATION : 1 mg/L
REFERENCE :
SAMJAF South African Medical Journal. (Medical Assoc. of South Africa,
Secy., P.O. Box 643, Cape Town, S. Africa) V.6- 1932-
Volume(issue)/page/year: 49,273,1975
TYPE OF TEST : DNA damage
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,235,1996
TYPE OF TEST : DNA adduct
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 250 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
48,207,1984
TYPE OF TEST : DNA adduct
TEST SYSTEM : Mammal - dog Cells - not otherwise specified
DOSE/DURATION : 1 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 3,1345,1982
TYPE OF TEST : DNA adduct
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Mammal - pig
DOSE/DURATION : 3100 ng/kg
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
32,249,1980
TYPE OF TEST : Unscheduled DNA synthesis
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Bird - chicken
DOSE/DURATION : 1 umol/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6,41,1984
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Mammal - cattle Cells - not otherwise specified
DOSE/DURATION : 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 194,73,1988
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 64 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
18,2783,1969
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bird - chicken Liver
DOSE/DURATION : 3 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
11,507,1975
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Bird - chicken
DOSE/DURATION : 3260 ug/kg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
21,87,1993
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Mammal - species unspecified Kidney
DOSE/DURATION : 12500 ug/L/8H (Continuous)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 8,617,1970
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Bird - chicken
DOSE/DURATION : 13 ng/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 2,435,1980
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Bird - chicken Embryo
DOSE/DURATION : 10 mg/L
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 173,481,1983
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 1,145,1972
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 10,51,1976
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 56,245,1993
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 56,245,1993
IARC Cancer Review:Group 1
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,83,1987
TOXICOLOGY REVIEW
LLOYA2 Lloydia. (Cincinnati, OH) V.1-41, 1938-78. For publisher
information, see JNPRDF. Volume(issue)/page/year: 38,21,1975
TOXICOLOGY REVIEW
IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013,
Israel) V.1- 1965- Volume(issue)/page/year: 10,441,1974
TOXICOLOGY REVIEW
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,225,1974
TOXICOLOGY REVIEW
BAREA8 Bacteriological Reviews. (Washington, DC) V.1-41, 1937-77.
Volume(issue)/page/year: 30,460,1966
TOXICOLOGY REVIEW
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year:
10,85,1974
TOXICOLOGY REVIEW
IJNDAN Indian Journal of Nutrition and Dietetics. (Sri Avinashilingam Home
Science College for Women, Coimbatore 641 043, India) V.7- 1970-
Volume(issue)/page/year: 8,85,1971
TOXICOLOGY REVIEW
ZHPMAT Zentralblatt fuer Bakteriologie, Parasitenkunde,
Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe B: Hygiene,
Krankenhaushygiene, Betriebshygiene, Praeventive Medizin. (Stuttgart, Fed.
Rep. Ger.) V.155-169, 1971-1979. For publisher information, see ZAOMDC.
Volume(issue)/page/year: 166,144,1978
TOXICOLOGY REVIEW
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York,
NY 10003) V.1- 1973- Volume(issue)/page/year: 24,129,1983
TOXICOLOGY REVIEW
ARMIAZ Annual Review of Microbiology. (Annual Reviews, Inc., POB 10139,
Palo Alto, CA 94303) V.1- 1947- Volume(issue)/page/year: 26,279,1972
TOXICOLOGY REVIEW
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
41,157,1977
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Body fluid assay;
Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: SHE-focus assay; Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-nonhuman;
Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; N crassa-forward
mutation
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; E coli polA
without S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; In vivo
SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS in rat liver; V79 cell
culture-gene mutation
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S
cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive/dose response: SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-human
lymphocytes
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-human; In
vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro UDS-human
fibroblast
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-rat; Sperm
morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Cytogenetics-male germ cell
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***