*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GY5977900
CHEMICAL NAME           : 3-Cyclopentene-1-heptanoic acid,
                          2-(3-hydroxy-1-octenyl)-5-oxo-
CAS REGISTRY NUMBER     : 14152-28-4
LAST UPDATED            : 198910
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C20-H32-O4
MOLECULAR WEIGHT        : 336.52
WISWESSER LINE NOTATION : T5V BUTJ D2YQ5 E6VQ
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * PGA1
   * PGA(sub 1)
   * PGA(sup 1)
   * Prosta-10,13-dien-1-oic acid, 15-hydroxy-9-oxo-, (13E,15S)-
   * Prostaglandin A1
   * Prostaglandin A(sub 1)
   * Prostaglandin A(sup 1)
   * Prostaglandin E(sup 1)-217
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 12 mg/kg
SEX/DURATION            : male 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   ANDRDQ Andrologia.  (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000
   Berlin 30, Fed. Rep. Ger.) V.6-    1974-  Volume(issue)/page/year:
   13,50,1981
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 169 ug/kg
SEX/DURATION            : female 17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   ACATA5 Acta Anatomica.  (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY
   10003)  V.1-    1945-  Volume(issue)/page/year: 95,40,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 169 ug/kg
SEX/DURATION            : female 17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - urogenital system
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   ACATA5 Acta Anatomica.  (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY
   10003)  V.1-    1945-  Volume(issue)/page/year: 95,40,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 10 mg/kg
SEX/DURATION            : female 16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   PRGLBA Prostaglandins.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1972-  Volume(issue)/page/year: 1,191,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 40 mg/kg
SEX/DURATION            : female 16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   PRGLBA Prostaglandins.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1972-  Volume(issue)/page/year: 1,191,1972
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 2500 ug/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,513,1983
 
                            *** END OF RECORD ***