*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GY8410000
CHEMICAL NAME           : 4H-Cyclopent(f)oxacyclotridecin-4-one,
                          1,6,7,8,9,11a-beta,12,13,14,14a-alpha-decahydro-1-
                          beta-13-alpha-dihydroxy-6-beta-methyl-
CAS REGISTRY NUMBER     : 20350-15-6
OTHER CAS REGISTRY NOS. : 3459-16-3
                          78206-62-9
LAST UPDATED            : 199412
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C16-H24-O4
MOLECULAR WEIGHT        : 280.40
WISWESSER LINE NOTATION : T5-13- IVO GU OUTJ CQ FQ K1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Ascotoxin
   * Brefeldin A
   * (+)-Brefeldin A
   * Cyanaein
   * Cyanein
   * Decumbin
   * Nectrolide
   * Synergisidin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJANAX Japanese Journal of Antibiotics.  (Japan Antibiotics Research Assoc.,
   2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)  V.21-    1968-
   Volume(issue)/page/year: 34,51,1981
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 200 ug/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 39,1148,1986
 
                            *** END OF RECORD ***