*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GZ0591850
CHEMICAL NAME           : 5H-Cyclopropa(3,4)benz(1,2-e)azulen-5-one,
                          1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-9,9a-
                          bis(benzoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1
                          ,6,8-tetramethyl-, (1aR-(1a-alpha,4b-
                          beta,4a-beta,7a-alpha,7b-alpha,8-alpha,9-beta,9a-alph
                          a))
CAS REGISTRY NUMBER     : 25405-85-0
OTHER CAS REGISTRY NOS. : 22391-37-3
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C34-H36-O8
MOLECULAR WEIGHT        : 572.70
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * Phorbol-12,13-dibenzoate
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7760 ug/kg/10W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   31,1074,1971
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1100 mg/kg/48W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - other Enzymes
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,4183,1979
 
                            *** END OF RECORD ***