*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : GZ0591907 CHEMICAL NAME : 5H-Cyclopropa(3,4)benz(1,2-e)azulen-5-one, 1,1a-alpha,1b-beta,4,4a,7a-alpha,7b,8,9,9a- decahydro-3-(hydroxymethyl)-4a-beta-methoxy-1,1,6,8-a lpha-tetramethyl-7b-a lpha,9-beta- 9a-alpha-trihydroxy-, 9-acetate 9a-tetradecanoate CAS REGISTRY NUMBER : 57716-89-9 LAST UPDATED : 198806 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C37-H58-O8 MOLECULAR WEIGHT : 630.95 WISWESSER LINE NOTATION : L E3 B676 MV IU NUTJ BQ C1 DOV1 EOV13 F1 F1 J1Q LO1 N1 COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * 4-O-Methyl-12-O-tetradecanoylphorbol-13-acetate * Me-Tpa * 4-O-Methyl-tpa *** HEALTH HAZARD DATA *** ** MUTATION DATA ** TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Fibroblast DOSE/DURATION : 20 mg/L REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 55,801,1975 TYPE OF TEST : Unscheduled DNA synthesis ROUTE OF EXPOSURE : Administration onto the skin TEST SYSTEM : Rodent - mouse DOSE/DURATION : 4 umol/kg REFERENCE : RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 24,533,1979 TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - guinea pig Cells - not otherwise specified DOSE/DURATION : 4 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,1975,1982 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-nonhuman *** END OF RECORD ***