*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GZ0591907
CHEMICAL NAME           : 5H-Cyclopropa(3,4)benz(1,2-e)azulen-5-one,
                          1,1a-alpha,1b-beta,4,4a,7a-alpha,7b,8,9,9a-
                          decahydro-3-(hydroxymethyl)-4a-beta-methoxy-1,1,6,8-a
                          lpha-tetramethyl-7b-a lpha,9-beta-
                          9a-alpha-trihydroxy-, 9-acetate 9a-tetradecanoate
CAS REGISTRY NUMBER     : 57716-89-9
LAST UPDATED            : 198806
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C37-H58-O8
MOLECULAR WEIGHT        : 630.95
WISWESSER LINE NOTATION : L E3 B676 MV IU NUTJ BQ C1 DOV1 EOV13 F1 F1 J1Q LO1
                          N1
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * 4-O-Methyl-12-O-tetradecanoylphorbol-13-acetate
   * Me-Tpa
   * 4-O-Methyl-tpa
 
                       *** HEALTH HAZARD DATA ***
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 20 mg/L
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   55,801,1975
 
TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 4 umol/kg
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 24,533,1979
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - guinea pig Cells - not otherwise specified
DOSE/DURATION           : 4 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   42,1975,1982

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-nonhuman

 
                            *** END OF RECORD ***