*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GZ0651000
CHEMICAL NAME           : 5H-Cyclopropa(3,4)benz(1,2-e)azulen-5-one,
                          1,1a-alpha,16-beta,4,4a,7a-alpha,7b,8,9,9a-
                          decahydro-4a-beta,7b-alpha,9-beta,9a-alpha-tetrahydro
                          xy-3-(hydroxymethyl)- 1,1,6,8-alpha- tetramethyl-,
                          9,9a-diacetate, (+)
CAS REGISTRY NUMBER     : 24928-15-2
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C24-H32-O8
MOLECULAR WEIGHT        : 448.56
WISWESSER LINE NOTATION : L E3 B675 MV IU NUTJ BQ C1 DOV1 EOV1 F1 F1 J1Q LQ N1
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Phorbol-12,13-diacetate
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 19 mg/kg/32W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   31,1074,1971
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 200 ug/tube
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   33,3103,1973
 
                            *** END OF RECORD ***