*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GZ1014000
CHEMICAL NAME           : Cyclopropanecarboxamide,
                          2-(aminomethyl)-N,N-diethyl-1-phenyl-, (Z)-,
                          monohydrochloride
CAS REGISTRY NUMBER     : 86181-08-0
LAST UPDATED            : 199604
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C15-H22-N2-O.Cl-H
MOLECULAR WEIGHT        : 282.85
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * (+-)-cis-2-Aminomethyl-N,N-diethyl-1-phenylcyclopropanecarboxamide  
   hydrochloride
   * (Z)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide  
   hydrochloride
   * Milnacipran
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 237 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 30,318,1987
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 315 mg/kg
SEX/DURATION            : female 63 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 28,3159,1994
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1680 mg/kg
SEX/DURATION            : female 14 day(s) pre-mating
                          female 1-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 28,3159,1994
 
                            *** END OF RECORD ***