*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GZ1251800
CHEMICAL NAME           : Cyclopropanecarboxylic acid,
                          2,2-dichloro-1-(4-ethoxyphenyl)-,
                          cyano(3-phenoxyphenyl) methyl ester
CAS REGISTRY NUMBER     : 63935-38-6
LAST UPDATED            : 199207
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C26-H21-Cl2-N-O4
MOLECULAR WEIGHT        : 482.38
COMPOUND DESCRIPTOR     : Agricultural Chemical
SYNONYMS/TRADE NAMES :
   * (RS)-alpha-Cyano-3-phenoxybenzyl  
   (RS)-2,2-dichloro-1-(4-ethoxyphenyl)cyclopropanecarboxylate
   * Cycloprothrin
   * Cyclosal
   * 2,2-Dichloro-1-(4-ethoxyphenyl)cyclopropanecarboxylic acid  
   cyano(3-phenoxyphenyl)methyl ester
   * GH 414
   * NK 8116
   * Phencyclate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPIFAN Japan Pesticide Information.  (Japan Plant Protection Assoc.,
   1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan)  No.1-61, 1969-92.  For
   publisher information, see AGJAEP.  Volume(issue)/page/year: (53),22,1988
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPIFAN Japan Pesticide Information.  (Japan Plant Protection Assoc.,
   1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan)  No.1-61, 1969-92.  For
   publisher information, see AGJAEP.  Volume(issue)/page/year: (53),22,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPIFAN Japan Pesticide Information.  (Japan Plant Protection Assoc.,
   1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan)  No.1-61, 1969-92.  For
   publisher information, see AGJAEP.  Volume(issue)/page/year: (53),22,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPIFAN Japan Pesticide Information.  (Japan Plant Protection Assoc.,
   1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan)  No.1-61, 1969-92.  For
   publisher information, see AGJAEP.  Volume(issue)/page/year: (53),22,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPIFAN Japan Pesticide Information.  (Japan Plant Protection Assoc.,
   1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan)  No.1-61, 1969-92.  For
   publisher information, see AGJAEP.  Volume(issue)/page/year: (53),22,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - quail
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPIFAN Japan Pesticide Information.  (Japan Plant Protection Assoc.,
   1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan)  No.1-61, 1969-92.  For
   publisher information, see AGJAEP.  Volume(issue)/page/year: (53),22,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - domestic
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMCHA2 Farm Chemicals Handbook.  (Meister Pub., 37841 Euclid Ave.,
   Willoughy, OH 44094)  Volume(issue)/page/year: -,C89,1991
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1699 mg/kg/13W-C
TOXIC EFFECTS :
   Liver - other changes
   Kidney, Ureter, Bladder - other changes
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 16,697,1991
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 82264 mg/kg/2Y-C
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Kidney, Ureter, Bladder - other changes
   Endocrine - adrenal cortex hyperplasia
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 16,697,1991
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 485 gm/kg/80W-C
TOXIC EFFECTS :
   Liver - other changes
   Kidney, Ureter, Bladder - other changes
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 16,697,1991
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 9100 mg/kg/26W-C
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Liver - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 16,697,1991
 
                            *** END OF RECORD ***