*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GZ1960000
CHEMICAL NAME           : Cyclopropanecarboxylic acid,
                          2,2-dimethyl-3-(2-methylpropenyl)-,
                          (2-methyl-5-(2-propynyl)- 3-furyl)methyl ester
CAS REGISTRY NUMBER     : 27223-49-0
LAST UPDATED            : 199512
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C19-H24-O3
MOLECULAR WEIGHT        : 300.43
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Kikuthrin
   * 2-Methyl-5-(2-propynyl)-3-furylmethyl-cis-trans-chrysanthemate
   * Proparthrin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 36,533,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BWHOA6 Bulletin of the World Health Organization.  (WHO, Pub. Center USA, 49
   Sheridan Ave., Albany, NY 12210)  Volume(issue)/page/year: 44,325,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 20 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BWHOA6 Bulletin of the World Health Organization.  (WHO, Pub. Center USA, 49
   Sheridan Ave., Albany, NY 12210)  Volume(issue)/page/year: 44,325,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   BOCKAF Bochu Kagaku.  Scientific Pest Control.  (Kyoto, Japan)  V.1-42,
   1937-77.  Discontinued.  Volume(issue)/page/year: 35,103,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BWHOA6 Bulletin of the World Health Organization.  (WHO, Pub. Center USA, 49
   Sheridan Ave., Albany, NY 12210)  Volume(issue)/page/year: 44,325,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >20 gm/kg
TOXIC EFFECTS :
   Behavioral - excitement
REFERENCE :
   BOCKAF Bochu Kagaku.  Scientific Pest Control.  (Kyoto, Japan)  V.1-42,
   1937-77.  Discontinued.  Volume(issue)/page/year: 35,103,1970
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1500 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   BOCKAF Bochu Kagaku.  Scientific Pest Control.  (Kyoto, Japan)  V.1-42,
   1937-77.  Discontinued.  Volume(issue)/page/year: 35,113,1970
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 6 gm/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   BOCKAF Bochu Kagaku.  Scientific Pest Control.  (Kyoto, Japan)  V.1-42,
   1937-77.  Discontinued.  Volume(issue)/page/year: 35,113,1970
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 30 gm/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   BOCKAF Bochu Kagaku.  Scientific Pest Control.  (Kyoto, Japan)  V.1-42,
   1937-77.  Discontinued.  Volume(issue)/page/year: 35,113,1970
 
                            *** END OF RECORD ***