*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HA4550000
CHEMICAL NAME           : Cytisine, 12-methyl-, hydrogen iodide
CAS REGISTRY NUMBER     : 20013-22-3
LAST UPDATED            : 199207
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C12-H16-N2-O.H-I
MOLECULAR WEIGHT        : 332.21
WISWESSER LINE NOTATION : T C666 A GVN LM&TTJ &IH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Caulophylline hydriodide
   * (-)-7R:9S-Caulophylline hydrogen iodide
   * Caulophylline, monohydriodide
   * N-Methylcytisine hydriodide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >830 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCBM British Journal of Pharmacology.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.34-    1968-  Volume(issue)/page/year:
   35,161,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 51 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   BJPCBM British Journal of Pharmacology.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.34-    1968-  Volume(issue)/page/year:
   35,161,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 21 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   BJPCBM British Journal of Pharmacology.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.34-    1968-  Volume(issue)/page/year:
   35,161,1969
 
                            *** END OF RECORD ***