*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HA5400000
CHEMICAL NAME           : Cytosine, 2,2'-anhydroarabino-5-fluoro-
CAS REGISTRY NUMBER     : 37717-21-8
BEILSTEIN REFERENCE NO. : 0891648
LAST UPDATED            : 199706
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C9-H10-F-N3-O4
MOLECULAR WEIGHT        : 243.22
WISWESSER LINE NOTATION : T B556 AN CO GO IN HHTT&J D1Q EQ JZ KF
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * AAFC
   * 2,2'-Anhydroarabino-5-fluorocytosine
   * Anhydro-ara-5-fluorocytidine
   * 2,2'-Anhydro-5-fluoro-1-beta-D-arabinofuranosylcytosine
   * Flurocitabine
   * NSC-166641
   * Ro 21-0702
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 33 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Blood - normocytic anemia
   Blood - leukopenia
REFERENCE :
   EJCAAH European Journal of Cancer.  (Oxford, UK)  V.1-17(6), 1965-1981. For
   publisher information, see EJCODS.  Volume(issue)/page/year: 14,195,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   23,2657,1974
 
                            *** END OF RECORD ***