*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : HA5600000 CHEMICAL NAME : Cytosine, 1-beta-D-arabino-furanosyl-, 2',3',5'-triacetate CAS REGISTRY NUMBER : 6742-07-0 LAST UPDATED : 199606 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C15-H19-N3-O8 MOLECULAR WEIGHT : 369.37 WISWESSER LINE NOTATION : T6NVNJ DZ A- BT5OTJ COV1 DOV1 E1OV1 COMPOUND DESCRIPTOR : Drug Mutagen SYNONYMS/TRADE NAMES : * 1-beta-D-Arabinofuranosyl-2',3',5'-triacetate * Cytosine arabinoside triacetate * NSC-93150 * 2(1H)-Pyrimidinone, 4-amino-1-(2,3,5-tri-O-acetyl-beta-D-arabinofuranosyl)- * Tri-O-acetylarabinosylcytosine *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5010 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCIHL* Progress Report Submitted to the National Cancer Institute by Hazelton Laboratories, Inc. (Falls Church, VA) Volume(issue)/page/year: -,353,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCIHL* Progress Report Submitted to the National Cancer Institute by Hazelton Laboratories, Inc. (Falls Church, VA) Volume(issue)/page/year: -,353,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 680 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCIHL* Progress Report Submitted to the National Cancer Institute by Hazelton Laboratories, Inc. (Falls Church, VA) Volume(issue)/page/year: -,353,1967 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg/5D-I TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : NCIHL* Progress Report Submitted to the National Cancer Institute by Hazelton Laboratories, Inc. (Falls Church, VA) Volume(issue)/page/year: -,353,1967 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 750 mg/kg/15D-I TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Blood - changes in bone marrow (not otherwise specified) Nutritional and Gross Metabolic - body temperature increase REFERENCE : NCIHL* Progress Report Submitted to the National Cancer Institute by Hazelton Laboratories, Inc. (Falls Church, VA) Volume(issue)/page/year: -,353,1967 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 3 gm/kg/15D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes primarily in glomeruli Blood - thrombocytopenia Related to Chronic Data - death REFERENCE : NCIHL* Progress Report Submitted to the National Cancer Institute by Hazelton Laboratories, Inc. (Falls Church, VA) Volume(issue)/page/year: -,353,1967 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 750 mg/kg/15D-I TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death REFERENCE : NCIHL* Progress Report Submitted to the National Cancer Institute by Hazelton Laboratories, Inc. (Falls Church, VA) Volume(issue)/page/year: -,353,1967 ** MUTATION DATA ** TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 49 umol/L REFERENCE : CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 49,2551,1984 *** END OF RECORD ***