*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GZ0617000
CHEMICAL NAME           : Decanoic acid, 9a-ester with
                          1,1a-alpha,1b-beta,4,4a,7a-alpha,7b,8,9,9a-decahydro-
                          3-
                          (hydroxymethyl)-4a-beta,7b-alpha,9-beta,9a-alpha-tetr
                          ahydroxy-1,1,6,8-alph a-tetramethyl-
                          5H-cyclopropa(3,4)benz(1,2-e)azulen-5-one 9-acetate
CAS REGISTRY NUMBER     : 20839-15-0
OTHER CAS REGISTRY NOS. : 16561-28-7
BEILSTEIN REFERENCE NO. : 2610782
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C32-H48-O8
MOLECULAR WEIGHT        : 560.80
COMPOUND DESCRIPTOR     : Tumorigen
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * 12-O-Acetyl-phorbol-13-decanoate
   * Phorbol acetate, caprate
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 49 ug
REACTION SEVERITY       : Mild
REFERENCE :
   PLMEAA Planta Medica.  (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart
   1, Fed. Rep. Ger.) V.1-    1953-  Volume(issue)/page/year: 22,241,1972
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 26 mg/kg/32W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   NATWAY Naturwissenschaften.  (Springer-Verlag, Heidelberger Platz 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.1-    1913-  Volume(issue)/page/year:
   54,282,1967
 
                            *** END OF RECORD ***