*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HG0525000
CHEMICAL NAME           : 11-Deoxycorticosterone, acetate
CAS REGISTRY NUMBER     : 56-47-3
BEILSTEIN REFERENCE NO. : 2570798
REFERENCE               : 4-08-00-02195 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C23-H32-O4
MOLECULAR WEIGHT        : 372.55
WISWESSER LINE NOTATION : L E5 B666 OV MUTJ A F FV1OV1
COMPOUND DESCRIPTOR     : Tumorigen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 21-Acetoxy-3,20-diketopregn-4-ene
   * Arcort
   * Bio-Corten
   * Cortacet
   * Cortate
   * Cortenil
   * Cortesan
   * Cortexone acetate
   * Corticosterone, deoxy-, acetate
   * Cortifar
   * Cortigen
   * Cortinaq
   * Cortiron
   * Cortivis
   * Cortixyl
   * DCA
   * Decortin
   * Decosterone
   * Decostrate
   * 11-Deoxycorticosterone 21-acetate
   * Deoxycortone acetate
   * Descorterone
   * Descotone
   * Desoxycorticosterone acetate
   * Desoxycortone acetate
   * DOCA
   * DOC acetate
   * Dorcostrin
   * Doxo
   * Doxycamon
   * 21-Hydroxypregn-4-ene-3,20-dione 21-acetate
   * Krinocorts
   * Ocriten
   * Organon's Doca Acetate
   * Percorten
   * Percotol
   * Pregn-4-ene-3,20-dione, 21-hydroxy-, acetate
   * 4-Pregnene-3,20-dione-21-ol acetate
   * Primocort
   * Primocortan
   * Sincortex
   * Steraq
   * Syncort
   * Syncorta
   * Syncortyl
   * Unidocan
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 520 mg/kg/13W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 83,14,1953
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1258 mg/kg
SEX/DURATION            : male 20 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   28,129,1941
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 316 mg/kg
SEX/DURATION            : female 56 day(s) pre-mating
                          female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 120,238,1965
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 224 mg/kg
SEX/DURATION            : female 56 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 120,238,1965
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 16 mg/kg
SEX/DURATION            : male 2 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
REFERENCE :
   ANENAG Annales d'Endocrinologie.  (Masson Editeur, 120 Blvd. Saint-Germain,
   F-25280 Paris Cedex 06, France)  V.1-    1939-  Volume(issue)/page/year:
   24(Suppl 3),1,1963

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   17,432,1957

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5546
       No. of Facilities: 17 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 968 (estimated)
       No. of Female Employees: 494 (estimated)

 
                            *** END OF RECORD ***