*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HG2994000
CHEMICAL NAME           : Deoxyribonucleic acid,
                          (d-P-thio)(G-C-C-G-A-G-G-T-C-C-A-T-G-T-C-G-T-A-C-G-C)
CAS REGISTRY NUMBER     : 141442-28-6
LAST UPDATED            : 199806
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C203-H257-N79-O105-P20-S20
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * ISIS 1082
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intradermal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 304 mg/kg/14D-I
TOXIC EFFECTS :
   Endocrine - changes in spleen weight
   Blood - changes in erythrocyte (RBC) count
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 116,77,1997
 
                            *** END OF RECORD ***