*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HH9246000
CHEMICAL NAME           : Dextran 40
CAS REGISTRY NUMBER     : 9004-54-0
LAST UPDATED            : 199701
DATA ITEMS CITED        : 7
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Low molecular dextran-L
   * Rheomacrodex
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 208 gm/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 3,201,1975
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2400 mL/kg/30D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Kidney, Ureter, Bladder - other changes
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 3,201,1975
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 3640 mL/kg/13W-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Kidney, Ureter, Bladder - other changes
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 3,201,1975
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE                    : 2 mL/kg
SEX/DURATION            : female 38 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   DRSAEA Drug Safety.  (Adis International Ltd.,  Private Bag 65901, Mairangi
   Bay, Auckland 10, New Zealand)  V.5-    1990-  Volume(issue)/page/year:
   7,71,1992

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83342
       No. of Facilities: 86 (estimated)
       No. of Industries: 3
       No. of Occupations: 4
       No. of Employees: 369 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 83342
       No. of Facilities: 432 (estimated)
       No. of Industries: 3
       No. of Occupations: 6
       No. of Employees: 7612 (estimated)
       No. of Female Employees: 4671 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***