*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HL5522000
CHEMICAL NAME           : Dianemycin,
                          10-demethyl-19-de((tetrahydro-5-methoxy-6-methyl-2H-p
                          yran-2-yl)oxy)-12-met hyl-
                          11-O-(tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl)-,
                          (11R(2R,5S,6R),12R)
CAS REGISTRY NUMBER     : 51257-84-2
LAST UPDATED            : 199106
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C47-H78-O13
MOLECULAR WEIGHT        : 851.25
WISWESSER LINE NOTATION : T6OXTJ C1 FY1&1UY1&VY1&1Y1&VQ DO- FT6OTJ B1 CO1& B-&
                          BT5OXTJ E1 E- FT6OXTJ C1 B-& BT5OXTJ C1
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Antibiotic A 130A
   * Antibiotic Ro 21 6150
   * Lenoremycin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson,
   M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978
   Volume(issue)/page/year: 3,47,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2520 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 5,500,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 34300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 5,500,1981
 
                            *** END OF RECORD ***