*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : HM2323000 CHEMICAL NAME : 1,3,2-Diazaphosphorine, hexahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide CAS REGISTRY NUMBER : 20982-36-9 BEILSTEIN REFERENCE NO. : 0785235 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C7-H16-Cl2-N3-O-P MOLECULAR WEIGHT : 260.13 WISWESSER LINE NOTATION : T6MPMTJ BO BN2G2G COMPOUND DESCRIPTOR : Drug Mutagen SYNONYMS/TRADE NAMES : * B 801 * 2-(Bis(2-chloroethyl)amino)hexahydro-1,3,2-diazaphosphorine 2-oxide * N,N-Bis-(beta-chloroethyl)-N',N''-propylenephosphoricacidtriamide * Phosphoric triamide, cyclic N,N'-trimethylene N''-bis(2-chloroethyl)- *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,143,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,477,1976 ** MUTATION DATA ** TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 10 mmol/L REFERENCE : DRISAA Drosophila Information Service. (Cold Spring Harbor Laboratory, POB 100, Cold Spring Harbor, NY 11724) No.1- 1934- Volume(issue)/page/year: 41,102,1966 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal *** END OF RECORD ***