*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HM2650000
CHEMICAL NAME           : 2,8-Diazaspiro(4,5)decane-1,3-dione,
                          8-(3-(p-fluorobenzoyl)propyl)-2-methyl-
CAS REGISTRY NUMBER     : 2804-00-4
BEILSTEIN REFERENCE NO. : 0763388
REFERENCE               : 5-24-07-00315 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C19-H23-F-N2-O3
MOLECULAR WEIGHT        : 346.44
WISWESSER LINE NOTATION : T6N DXTJ A3VR DF& D-& CT5VNVX EHJ A
SYNONYMS/TRADE NAMES :
   * F-33
   *   8-(4-p-Fluorophenyl-4-oxobutyl)-2-methyl-2,8-diazaspiro(4.5)decane-1,3-d
     ione
   * FR-33
   *   8-(3-(p-Fluorobenzoyl)propyl)-2-methyl-2,8-diazaspiro(4.5)decane-1,3-dio
     ne
   * R 7158
   * Roxoperone
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 92 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,189,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 193 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,189,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,189,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,189,1972
 
                            *** END OF RECORD ***