*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HM3675000
CHEMICAL NAME           : 1H-1,4-Diazepine,
                          1-(p-chloro-alpha-phenylbenzyl)hexahydro-4-methyl-,
                          dihydrochloride
CAS REGISTRY NUMBER     : 1982-36-1
LAST UPDATED            : 199009
DATA ITEMS CITED        : 14
MOLECULAR FORMULA       : C19-H23-Cl-N2.2Cl-H
MOLECULAR WEIGHT        : 387.81
WISWESSER LINE NOTATION : T7N DNTJ AYR&R DG& D1 &GH 2
SYNONYMS/TRADE NAMES :
   * 1-(p-Chloro-alpha-phenylbenzyl)hexahydro-4-methyl-1H-1,4-diazepine,  
   dihydrochloride
   * 1-H,4-Diazepine, 1-(p-chloro-alpha-phenylbenzyl)hexahydro-4-methyl-,  
   dihydrochloride
   * Homochlorcyclizine, dihydrochloride
   * Homochlorocyclizine, dihydrochloride
   * SA 97 dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 490 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JOALAS Journal of Allergy.  (St. Louis, MO)  V.1-47, 1929-71.  For publisher
   information, see JACIBY.  Volume(issue)/page/year: 31,237,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   JOALAS Journal of Allergy.  (St. Louis, MO)  V.1-47, 1929-71.  For publisher
   information, see JACIBY.  Volume(issue)/page/year: 31,237,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 36 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory stimulation
   Behavioral - tremor
   Behavioral - excitement
REFERENCE :
   JOALAS Journal of Allergy.  (St. Louis, MO)  V.1-47, 1929-71.  For publisher
   information, see JACIBY.  Volume(issue)/page/year: 31,237,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 390 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
   Behavioral - ataxia
REFERENCE :
   JOALAS Journal of Allergy.  (St. Louis, MO)  V.1-47, 1929-71.  For publisher
   information, see JACIBY.  Volume(issue)/page/year: 31,237,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Behavioral - muscle contraction or spasticity
REFERENCE :
   JOALAS Journal of Allergy.  (St. Louis, MO)  V.1-47, 1929-71.  For publisher
   information, see JACIBY.  Volume(issue)/page/year: 31,237,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Behavioral - muscle contraction or spasticity
REFERENCE :
   JOALAS Journal of Allergy.  (St. Louis, MO)  V.1-47, 1929-71.  For publisher
   information, see JACIBY.  Volume(issue)/page/year: 31,237,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 47 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Behavioral - muscle contraction or spasticity
REFERENCE :
   JOALAS Journal of Allergy.  (St. Louis, MO)  V.1-47, 1929-71.  For publisher
   information, see JACIBY.  Volume(issue)/page/year: 31,237,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
   Behavioral - muscle contraction or spasticity
REFERENCE :
   JOALAS Journal of Allergy.  (St. Louis, MO)  V.1-47, 1929-71.  For publisher
   information, see JACIBY.  Volume(issue)/page/year: 31,237,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JOALAS Journal of Allergy.  (St. Louis, MO)  V.1-47, 1929-71.  For publisher
   information, see JACIBY.  Volume(issue)/page/year: 31,237,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle contraction or spasticity
REFERENCE :
   JOALAS Journal of Allergy.  (St. Louis, MO)  V.1-47, 1929-71.  For publisher
   information, see JACIBY.  Volume(issue)/page/year: 31,237,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JOALAS Journal of Allergy.  (St. Louis, MO)  V.1-47, 1929-71.  For publisher
   information, see JACIBY.  Volume(issue)/page/year: 31,237,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 390 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Behavioral - muscle contraction or spasticity
REFERENCE :
   JOALAS Journal of Allergy.  (St. Louis, MO)  V.1-47, 1929-71.  For publisher
   information, see JACIBY.  Volume(issue)/page/year: 31,237,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 76 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JOALAS Journal of Allergy.  (St. Louis, MO)  V.1-47, 1929-71.  For publisher
   information, see JACIBY.  Volume(issue)/page/year: 31,237,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 19 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JOALAS Journal of Allergy.  (St. Louis, MO)  V.1-47, 1929-71.  For publisher
   information, see JACIBY.  Volume(issue)/page/year: 31,237,1960
 
                            *** END OF RECORD ***