*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HO1650000
CHEMICAL NAME           : 5H-Dibenz(b,f)azepine,
                          5-(3-(dimethylamino)propyl)-10,11-dihydro-, and
                          3H-1,4- benzodiazepine,
                          7-chloro-2-(methylamino)-5-phenyl-, 4-oxide (2:1)
CAS REGISTRY NUMBER     : 63918-77-4
LAST UPDATED            : 198910
DATA ITEMS CITED        : 1
COMPOUND DESCRIPTOR     : Human
SYNONYMS/TRADE NAMES :
   * Chlordiazepoxide and imipramine (1:2)
   * Chlordiazepoxide and tofranil (1:2)
   * Imipramine and chlordiazepoxide (2:1)
   * Tofranil and chlordiazepoxide (2:1)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 21 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Behavioral - muscle contraction or spasticity
   Behavioral - antipsychotic
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   3,619,1961
 
                            *** END OF RECORD ***