*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HO7030000
CHEMICAL NAME           : Dibenzo(b,def)chrysene-7,14-dione
CAS REGISTRY NUMBER     : 128-66-5
BEILSTEIN REFERENCE NO. : 2000679
REFERENCE               : 4-07-00-02709 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C24-H12-O2
MOLECULAR WEIGHT        : 332.36
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * Ahcovat Printing Golden Yellow
   * Amanthrene Golden Yellow
   * Anthravat Golden Yellow
   * Arlanthrene Golden Yellow
   * Benzadone Golden Yellow
   * Calcoloid Golden Yellow
   * Caledon Golden Yellow
   * Caledon Printing Yellow
   * Carbanthrene Golden Yellow
   * C.I. 59100
   * Cibanone Golden Yellow
   * C.I. Vat Yellow
   * C.I. Vat Yellow 4
   * Dibenzo(a,b)pyrene-7,14-dione
   * 2,3,7,8-Dibenzopyrene-1,6-quinone
   * 1',2',6',7'-Dibenzpyrene-7,14-quinone
   * Femanthren Golden Yellow
   * Golden Yellow
   * Helanthrene Yellow
   * Hostavat Golden Yellow
   * Indanthrene Golden Yellow
   * Indanthren Golden Yellow
   * Indanthren Printing Yellow
   * Leucosol Golden Yellow
   * Mayvat Golden Yellow
   * Mikethrene Gold Yellow
   * NCI-C03565
   * Nihonthrene Golden Yellow
   * Nyanthrene Golden Yellow
   * Palanthrene Golden Yellow
   * Paradone Golden Yellow GK
   * Pharmanthrene Golden Yellow
   * Romantrene Golden Yellow
   * Sandothrene Golden Yellow
   * Sandothrene Printing Yellow
   * Solanthrene Brilliant Yellow
   * Tinon Golden Yellow GK
   * Tyrian Yellow I-GOK
   * Vat Golden Yellow
   * Vat Golden Yellow ZhKh
   * Vat Golden Yellow ZhKhD
   * Vat Yellow 4
   * Yellow
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 27(4),54,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2270 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 27(4),54,1983
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 79500 mg/kg/6W-I
TOXIC EFFECTS :
   Liver - liver function tests impaired
   Blood - pigmented or nucleated red blood cells
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 27(4),54,1983
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7420 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-134,1979
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2225 gm/kg/106W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-134,1979

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Limited Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 48,161,1990

   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 48,161,1990

   IARC Cancer Review:Group 3
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 48,161,1990

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   NCI Carcinogenesis Bioassay (feed);clear evidence:mouse
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-134,79

   NCI Carcinogenesis Bioassay (feed);no evidence:rat
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-134,79

 
                            *** END OF RECORD ***