*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HP5270000
CHEMICAL NAME           : 1,3(2H,9bH)-dibenzofurandione,
                          2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-
CAS REGISTRY NUMBER     : 125-46-2
BEILSTEIN REFERENCE NO. : 1299865
LAST UPDATED            : 199701
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C18-H16-O7
MOLECULAR WEIGHT        : 344.34
WISWESSER LINE NOTATION : T B656 CV EV HO FU BHT&&J B1 DV1 JV1 KQ L1 MQ
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bh)-dibenzofurandione
   * Usnein
   * Usniacin
   * Usnic acid
   * Usninic acid
   * Usninsaeure
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 9,89,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ANTBDO Antibiotics. (Springer-Verlag New York, Inc., Service Cetner, 44
   Hartz Way, Secaucus, NJ 07094)  V.1-6,    1967-83. Discontinued
   Volume(issue)/page/year: 1,611,1967
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 5,510,1955
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 20 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Mammal - species unspecified Cells - not otherwise
                          specified
DOSE/DURATION           : 3750 ug/L
REFERENCE :
   PHMCAA Pharmacologist.  (American Soc. for Pharmacology and Experimental
   Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014)  V.1-    1959-
   Volume(issue)/page/year: 12,280,1970

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***