*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : HP5270000 CHEMICAL NAME : 1,3(2H,9bH)-dibenzofurandione, 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl- CAS REGISTRY NUMBER : 125-46-2 BEILSTEIN REFERENCE NO. : 1299865 LAST UPDATED : 199701 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C18-H16-O7 MOLECULAR WEIGHT : 344.34 WISWESSER LINE NOTATION : T B656 CV EV HO FU BHT&&J B1 DV1 JV1 KQ L1 MQ COMPOUND DESCRIPTOR : Drug Mutagen SYNONYMS/TRADE NAMES : * 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bh)-dibenzofurandione * Usnein * Usniacin * Usnic acid * Usninic acid * Usninsaeure *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 9,89,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANTBDO Antibiotics. (Springer-Verlag New York, Inc., Service Cetner, 44 Hartz Way, Secaucus, NJ 07094) V.1-6, 1967-83. Discontinued Volume(issue)/page/year: 1,611,1967 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,510,1955 ** MUTATION DATA ** TYPE OF TEST : DNA adduct TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 20 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981 TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Mammal - species unspecified Cells - not otherwise specified DOSE/DURATION : 3750 ug/L REFERENCE : PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 12,280,1970 *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***