*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HP6475000
CHEMICAL NAME           : Dibenzo(a,h)phenazine
CAS REGISTRY NUMBER     : 226-47-1
BEILSTEIN REFERENCE NO. : 0217195
REFERENCE               : 5-23-10-00184 (Beilstein Handbook Reference)
LAST UPDATED            : 199803
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C20-H12-N2
MOLECULAR WEIGHT        : 280.34
WISWESSER LINE NOTATION : T G6 D6 B666 CN NNJ
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 7,14-Diazadibenz(a,h)anthracene
   * 1,2,5,6-Dibenzophenazine
   * Dibenz(a,h)phenazine
   * 1,2:5,6-Dibenzphenazine
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
   (Paris, France)  V.1-261, 1835-1965.  For publisher information, see CRASEV.
    Volume(issue)/page/year: 240,1738,1955
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   NEOLA4 Neoplasma.  (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
      1957-  Volume(issue)/page/year: 25,641,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 1800 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   30,195,1970

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal

 
                            *** END OF RECORD ***