*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HP8525000
CHEMICAL NAME           : 6H-Dibenzo(b,d)pyran-1-ol,
                          6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-,
                          acetate, (6aR-trans)-
CAS REGISTRY NUMBER     : 23132-17-4
LAST UPDATED            : 199206
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C23-H32-O3
MOLECULAR WEIGHT        : 356.55
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Tetrahydrocannabinol acetate
   * THC
   * Acetic acid, tetrahydrocannabinol ester
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - rigidity (including catalepsy)
   Gastrointestinal - decreased motility or constipation
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 88,154,1946
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Gastrointestinal - changes in structure or function of salivary glands
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 88,154,1946
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 155 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - rigidity (including catalepsy)
   Gastrointestinal - decreased motility or constipation
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 88,154,1946
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 820 mg/kg
SEX/DURATION            : female 5-21 day(s) after conception
                          lactating female 24 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - endocrine system
REFERENCE :
   NRSCDN Neuroscience.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3
   OBW, UK)  V.1-    1976-  Volume(issue)/page/year: 43,713,1991
 
                            *** END OF RECORD ***