*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HQ3000000
CHEMICAL NAME           : Dibenzo(b,e)thiepin-delta(sup
                          11(6H),gamma)-propylamine, N,N-dimethyl-, 5-oxide,
                          maleate (1:1), (Z)-
CAS REGISTRY NUMBER     : 25627-41-2
LAST UPDATED            : 199412
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C19-H21-N-O-S.C4-H4-O4
MOLECULAR WEIGHT        : 427.55
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * cis-11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepin  
   5-oxide hydrogen maleate
   * cis-Prothiadene-S-oxide hydrogen maleate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 34,1963,1969
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 4295 mg/kg/28D-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Skin and Appendages - dermatitis, irritative (after systemic exposure)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 4,41,1975
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 36 mg/kg
SEX/DURATION            : female 14-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
   Endocrine - changes in luteinizing hormone
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   JOAND3 Journal of Andrology.  (Lippincott/Harper, Journal Fulfillment Dept.,
   2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1980-
   Volume(issue)/page/year: 6,386,1985
 
                            *** END OF RECORD ***