*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : HQ3000000 CHEMICAL NAME : Dibenzo(b,e)thiepin-delta(sup 11(6H),gamma)-propylamine, N,N-dimethyl-, 5-oxide, maleate (1:1), (Z)- CAS REGISTRY NUMBER : 25627-41-2 LAST UPDATED : 199412 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C19-H21-N-O-S.C4-H4-O4 MOLECULAR WEIGHT : 427.55 COMPOUND DESCRIPTOR : Drug Reproductive Effector SYNONYMS/TRADE NAMES : * cis-11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepin 5-oxide hydrogen maleate * cis-Prothiadene-S-oxide hydrogen maleate *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Behavioral - excitement REFERENCE : CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 34,1963,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 4295 mg/kg/28D-I TOXIC EFFECTS : Liver - changes in liver weight Skin and Appendages - dermatitis, irritative (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 4,41,1975 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 36 mg/kg SEX/DURATION : female 14-19 day(s) after conception TOXIC EFFECTS : Reproductive - Paternal Effects - other effects on male Endocrine - changes in luteinizing hormone Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) REFERENCE : JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980- Volume(issue)/page/year: 6,386,1985 *** END OF RECORD ***