*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : HQ9275000
CHEMICAL NAME : Diborane(6)
CAS REGISTRY NUMBER : 19287-45-7
LAST UPDATED : 199712
DATA ITEMS CITED : 35
MOLECULAR FORMULA : B2-H6
MOLECULAR WEIGHT : 27.68
WISWESSER LINE NOTATION : H6 B2
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* Boroethane
* Boron hydride
* Diborane
* Diboron hexahydride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 40 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New
York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 29 ppm/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - acute pulmonary edema
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
4,215,1962
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 125 ppm/2H
TOXIC EFFECTS :
Brain and Coverings - changes in surface EEG
Lungs, Thorax, or Respiration - acute pulmonary edema
Blood - hemorrhage
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 13,346,1956
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 50 ppm/8H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 21,519,1960
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 ppb/6H/8W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Blood - pigmented or nucleated red blood cells
Nutritional and Gross Metabolic - changes in sodium
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
138,1977,1996
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5 ppm/6H/4W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Blood - changes in erythrocyte (RBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
69,397,1995
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 2000 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 307,335,1994
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 5000 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 307,335,1994
*** REVIEWS ***
ACGIH TLV-TWA 0.11 mg/m3 (0.1 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 6,497,1973
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.1 ppm (0.1 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,72,1971
OSHA PEL (Gen Indu):8H TWA 0.1 ppm (0.1 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.1 ppm (0.1 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.1 ppm (0.1 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.1 ppm (0.1 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.1 ppm (0.1 mg/m3) JAN 1993
OEL-AUSTRIA:TWA 0.1 ppm (0.1 mg/m3) JAN 1993
OEL-BELGIUM:TWA 0.1 ppm (0.11 mg/m3) JAN 1993
OEL-DENMARK:TWA 0.1 ppm (0.1 mg/m3) JAN 1993
OEL-FINLAND:TWA 0.1 ppm (0.1 mg/m3);STEL 0.3 ppm (0.3 mg/m3) JAN 1993
OEL-FRANCE:TWA 0.1 ppm (0.1 mg/m3) JAN 1993
OEL-GERMANY:TWA 0.1 ppm (0.1 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 ppm (0.1 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 0.1 ppm (0.1 mg/m3) JAN 1993
OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.1 ppm (0.1 mg/m3);STEL 0.2 ppm (0.2 mg/m3) JAN 1993
OEL-TURKEY:TWA 0.1 ppm (0.1 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 ppm (0.1 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO DIBORANE-air:10H TWA 0.1 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 23650
No. of Facilities: 24 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 409 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 23650
No. of Facilities: 24 (estimated)
No. of Industries: 4
No. of Occupations: 12
No. of Employees: 4616 (estimated)
No. of Female Employees: 1271 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NIOSH Analytical Method, 1994: Diborane, 6006
*** END OF RECORD ***