*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HZ4300000
CHEMICAL NAME           : 5,34:16,21-Diethenodibenzo(b,r)(1,5,16,20)tetraazacyc
                          lotriaconti-5,16-diiu m, 6,7,8,9,10,11,
                          12,13,14,15,22,23,24,25,26,27,28,29,30,31,32,33-docos
                          ahydro-36,38-dimethyl -, dibromide
CAS REGISTRY NUMBER     : 16776-40-2
LAST UPDATED            : 198703
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C40-H58-N4.2Br
MOLECULAR WEIGHT        : 754.84
WISWESSER LINE NOTATION : T6 S6 R6-30-6/R--B&/GQ& 4AFSA& Q& GK RK C&M N&MJ &E 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * N(sup 1),N(sup 1)'-Dekamethylen-N(sup 4),N(sup  
   4)'-dekamethylen-bis-4-amino-chinaldinium
   * Quinaldinium, 1,1'-decamethylene-4,4'-(decamethylenediimino)di-,  
   dibromide
   * R 199
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1700 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 10,687,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 10,687,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 52500 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 10,687,1960
 
                            *** END OF RECORD ***