*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AM1050000
CHEMICAL NAME           : Acetonitrile, ((alpha-methylphenethyl)amino)phenyl-
CAS REGISTRY NUMBER     : 17590-01-1
BEILSTEIN REFERENCE NO. : 2056148
LAST UPDATED            : 199706
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C17-H18-N2
MOLECULAR WEIGHT        : 250.37
WISWESSER LINE NOTATION : NCYR&MY1&1R
SYNONYMS/TRADE NAMES :
   * Amphetaminil
   * N-(alpha-Methylphenethyl)-2-phenylglycinonitrile
   * alpha-Phenyl-alpha-(1-methyl-2-phenyl)ethylaminoacetonitrile
   * alpha-Phenyl-alpha(beta-phenylisopropylamino)acetonitrile
   * alpha-Phenyl-alpha-N-(1-phenylisopropyl)aminoacetonitrile
   * dl-Amphetaminil
   * AN 1 (pharmaceutical)
   * Aponeuron
   * Benzeneacetonitrile, alpha-((1-methyl-2-phenylethyl)amino)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 37600 ug/kg
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
   Vascular - BP elevation not characterized in autonomic section
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   TOIZAG Toho Igakkai Zasshi.  Journal of Medical Society of Toho University.
   (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
   Japan)  V.1-    1954-  Volume(issue)/page/year: 24,823,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 58800 ug/kg
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
   Vascular - BP elevation not characterized in autonomic section
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   TOIZAG Toho Igakkai Zasshi.  Journal of Medical Society of Toho University.
   (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
   Japan)  V.1-    1954-  Volume(issue)/page/year: 24,823,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 95100 ug/kg
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
   Vascular - BP elevation not characterized in autonomic section
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   TOIZAG Toho Igakkai Zasshi.  Journal of Medical Society of Toho University.
   (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
   Japan)  V.1-    1954-  Volume(issue)/page/year: 24,823,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 182 mg/kg
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
   Vascular - BP elevation not characterized in autonomic section
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   TOIZAG Toho Igakkai Zasshi.  Journal of Medical Society of Toho University.
   (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
   Japan)  V.1-    1954-  Volume(issue)/page/year: 24,823,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 491 mg/kg
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
   Vascular - BP elevation not characterized in autonomic section
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   TOIZAG Toho Igakkai Zasshi.  Journal of Medical Society of Toho University.
   (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
   Japan)  V.1-    1954-  Volume(issue)/page/year: 24,823,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 58 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,335,1972
 
                            *** END OF RECORD ***