*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AM4550000
CHEMICAL NAME           : p-Acetophenetidide, 3-nitro-
CAS REGISTRY NUMBER     : 1777-84-0
BEILSTEIN REFERENCE NO. : 2735844
REFERENCE               : 3-13-00-01202 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C10-H12-N2-O4
MOLECULAR WEIGHT        : 224.24
WISWESSER LINE NOTATION : WNR BO2 EMV1
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * 4-Acetamino-2-nitrophenetole
   * p-Acetophenetide, 3'-nitro-
   * 4-Ethoxy-3-nitroanilid kyseliny octove
   * N-(4-Ethoxy-3-nitro)phenylacetamide
   * N-(4-Ethoxyphenyl)-3'-nitroacetamide
   * NCI-C01978
   * 2-Nitro-4-acetaminofenetol
   * 3-Nitro-p-acetophenetide
   * 3'-Nitro-p-acetophenetide
   * 5-Nitro-p-acetophenetidide
   * 3'-Nitro-p-acetophenetidin
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/24H
REACTION SEVERITY       : Moderate
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,708,1986
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 957 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-133,1979
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 478 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-133,1979
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 5(Suppl
   1),3,1983

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   NCI Carcinogenesis Bioassay (feed);clear evidence:mouse
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-133,79

   NCI Carcinogenesis Bioassay (feed);no evidence:rat
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-133,79

 
                            *** END OF RECORD ***