*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AM9158000
CHEMICAL NAME           : Acetophenone,
                          2-(3-(m-hydroxyphenyl)-2,3-dimethylpiperidino)-,
                          hydrochloride
CAS REGISTRY NUMBER     : 4370-33-6
LAST UPDATED            : 199410
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C21-H25-N-O2.Cl-H
MOLECULAR WEIGHT        : 359.93
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * m-(1-Benzoylmethyl-2,3-dimethyl-3-piperidyl)phenol hydrochloride
   * Ethanone, 2-(3-(3-hydroxyphenyl)-2,3-dimethyl-1-piperidinyl)-1-phenyl-,  
   hydrochloride
   * 2-(3-(m-Hydroxyphenyl)-2,3-dimethylpiperidino)acetophenone hydrochloride
   * 1-Phenacyl-2,3-dimethyl-3-(3-hydroxyphenyl)piperidine hydrochloride
   * TA-306
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 18,406,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 234 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 18,406,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >800 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 18,406,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 117 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 18,406,1968
 
                            *** END OF RECORD ***