*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AN3457000
CHEMICAL NAME           : p-Acetotoluidide, 2-(diethylamino)-, hydrochloride
CAS REGISTRY NUMBER     : 13995-54-5
LAST UPDATED            : 199309
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C13-H20-N2-O.Cl-H
MOLECULAR WEIGHT        : 256.81
WISWESSER LINE NOTATION : 2N2&1VMR D1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Acetamide, 2-(diethylamino)-N-(4-methylphenyl)-, monohydrochloride
   * 2-(Diethylamino)-p-acetotoluidide hydrochloride
   * omega-Diethylamino methyl-4 acetanilide chlorhydrate
   * 2-(Diethylamino)-4'-methylacetanilide monohydrochloride
   * IEM-218
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   PHTXA6 Pharmacology and Toxicology.  English translation of FATOAO.  (New
   York, NY)  V.20-22, 1957-59.  Discontinued.  Volume(issue)/page/year:
   21,144,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 24,539,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 81 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 25,629,1991
 
                            *** END OF RECORD ***