*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : AN7525000
CHEMICAL NAME : 2',6'-Acetoxylidide, 2-(diethylamino)-
CAS REGISTRY NUMBER : 137-58-6
BEILSTEIN REFERENCE NO. : 2215784
REFERENCE : 4-12-00-02538 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 30
MOLECULAR FORMULA : C14-H22-N2-O
MOLECULAR WEIGHT : 234.38
WISWESSER LINE NOTATION : 2N2&1VMR B1 F1
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-
* Anestacon
* Diethylaminoaceto-2,6-xylidide
* alpha-Diethylaminoaceto-2,6-xylidide
* alpha-Diethylamino-2,6-acetoxylidide
* 2-(Diethylamino)-2',6'-acetoxylidide
* Diethylaminoacet-2,6-xylidide
* alpha-Diethylamino-2,6-dimethylacetanilide
* omega-Diethylamino-2,6-dimethylacetanilide
* 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
* alfa-Dietilamino-2,6-dimetilacetanilide
* Duncaine
* Gravocain
* Isicaina
* Isicaine
* Leostesin
* Lida-mantle
* Lidocaine
* Lignocaine
* Maricaine
* Rucaina
* Solcain
* Xilocaina
* Xycaine
* Xylestesin
* Xylocain
* Xylocaine
* Xylocitin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraspinal
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 1 mL/kg
TOXIC EFFECTS :
Behavioral - euphoria
Behavioral - hallucinations, distorted perceptions
REFERENCE :
JCPYDR Journal of Clinical Pyschopharmacology. (Williams & Wilkins Co., 428
E. Preston St., Baltimore, MD 21202) V.1- 1981- Volume(issue)/page/year:
10,442,1990
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - child
DOSE/DURATION : 21 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year:
30,413,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 39 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Behavioral - excitement
Cardiac - change in rate
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10
Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year:
306,381,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - child
DOSE/DURATION : 300 mg/kg/5D-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Vascular - BP lowering not characterized in autonomic section
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
PECAE5 Pediatric Emergency Care. (Williams & Wilkins, 428 E. Preston St.,
Baltimore, MD 21202) V.1- 1985- Volume(issue)/page/year: 10,344,1994
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 16 mg/kg
TOXIC EFFECTS :
Cardiac - change in rate
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
EJCPAS European Journal of Clinical Pharmacology. (Springer-Verlag New
York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1970-
Volume(issue)/page/year: 22,129,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - man
DOSE/DURATION : 8643 ug/kg/4H-C
TOXIC EFFECTS :
Behavioral - toxic psychosis
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200
Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year:
97,149,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human
DOSE/DURATION : 23 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74.
For publisher information, see ARTODN. Volume(issue)/page/year: 28,72,1971
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - man
DOSE/DURATION : 1700 ug/kg/2M-C
TOXIC EFFECTS :
Behavioral - coma
Cardiac - pulse rate
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia,
PA) V.1- 1983- Volume(issue)/page/year: 4,143,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 317 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica,
Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year:
110,330,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 133 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 243,97,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 335 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
(Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
V.9- 1974- Volume(issue)/page/year: 9,188,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #5264432
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 39400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 54(3),32,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 220 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - rigidity (including catalepsy)
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 16,1275,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 102 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - local anesthetic
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 24,1059,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 238 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 28,714,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 123,269,1958
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 41 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
31,273,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
Italy) V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 10,883,1955
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 130,235,1961
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Human - woman
DOSE : 540 ug/kg
SEX/DURATION : female 39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB
560B, Kennebunkport, ME 04046) V.1- 1926- Volume(issue)/page/year:
64,934,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE : 6 mg/kg
SEX/DURATION : female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
8,61,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 6 mg/kg
SEX/DURATION : female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - sex ratio
REFERENCE :
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year:
11,395,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 6 mg/kg
SEX/DURATION : female 18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year:
11,395,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - rat
DOSE : 7500 mg/kg
SEX/DURATION : female 3-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 33,73C,1986
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 50 umol/plate
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.1- 1953- Volume(issue)/page/year: 34,157,1986
*** REVIEWS ***
TOXICOLOGY REVIEW
BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of
Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925-
Volume(issue)/page/year: 52,222,1976
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84482
No. of Facilities: 443 (estimated)
No. of Industries: 3
No. of Occupations: 7
No. of Employees: 5743 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84482
No. of Facilities: 763 (estimated)
No. of Industries: 1
No. of Occupations: 15
No. of Employees: 51880 (estimated)
No. of Female Employees: 43813 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***