*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AR5562700
CHEMICAL NAME           : Aconitane-3,8,13,14,15-pentol,
                          4-(methoxymethyl)-20-methyl-1,6,16-trimethoxy-,
                          8-acetate 14- benzoate, hydrobromide,
                          (1-alpha,3-alpha,6-alpha,14-alpha,15-alpha,16-beta)-
CAS REGISTRY NUMBER     : 71425-64-4
LAST UPDATED            : 198809
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C33-H45-N-O11.Br-H
MOLECULAR WEIGHT        : 712.71
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Mesaconitine hydrobromide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2143 ug/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TJEMAO Tohoku Journal of Experimental Medicine.  (Maruzen Co. Ltd., Export
   Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan)  V.1-    1920-
   Volume(issue)/page/year: 128,175,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 240 ug/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TJEMAO Tohoku Journal of Experimental Medicine.  (Maruzen Co. Ltd., Export
   Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan)  V.1-    1920-
   Volume(issue)/page/year: 128,175,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 230 ug/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TJEMAO Tohoku Journal of Experimental Medicine.  (Maruzen Co. Ltd., Export
   Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan)  V.1-    1920-
   Volume(issue)/page/year: 128,175,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 113 ug/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TJEMAO Tohoku Journal of Experimental Medicine.  (Maruzen Co. Ltd., Export
   Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan)  V.1-    1920-
   Volume(issue)/page/year: 128,175,1979
 
                            *** END OF RECORD ***