*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : JF7980000
CHEMICAL NAME : 18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,
21-chloro-13-ethyl-17-hydroxy-, mixed with
3-methoxy-17-alpha-19-norpregna-1,3,5(10)trien-20-yn-
17-ol
LAST UPDATED : 198910
DATA ITEMS CITED : 3
COMPOUND DESCRIPTOR : Tumorigen
Drug
SYNONYMS/TRADE NAMES :
* Chloroethynyl norgestrel mixed with mestranol (20:1)
* Mestranol mixed with chloroethynyl norgestrel (1:20)
* Wy-4355 mixed with Mestranol (20:1)
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 463 mg/kg/90W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumor types after systemic administration not seen
spontaneously
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 65,137,1980
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 423 mg/kg/4Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 3,179,1977
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 383 mg/kg/4Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
59,933,1977
*** END OF RECORD ***