*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : JG6813000
CHEMICAL NAME           : 2,3-Dioxabicyclo(3.3.1)nonan-7-one,
                          4-(2-(2,4-bis(trifluoromethyl)phenyl)ethenyl)-4,8-
                          dimethyl-, (1S-(1-alpha,4-beta(Z),5-alpha,8-beta))-
CAS REGISTRY NUMBER     : 123407-36-3
LAST UPDATED            : 199606
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C19-H18-F6-O3
MOLECULAR WEIGHT        : 408.37
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Arteflene
   * Ro 42-1611
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TMPRAD Tropenmedizin und Parasitologie.  (Georg Thieme Verlag, Postfach 732,
   D-7000 Stuttgart 1, Fed. Rep. Ger.)  V.25-    1974- Volume(issue)/page/year:
   45,261,1994
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   TMPRAD Tropenmedizin und Parasitologie.  (Georg Thieme Verlag, Postfach 732,
   D-7000 Stuttgart 1, Fed. Rep. Ger.)  V.25-    1974- Volume(issue)/page/year:
   45,261,1994
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   TMPRAD Tropenmedizin und Parasitologie.  (Georg Thieme Verlag, Postfach 732,
   D-7000 Stuttgart 1, Fed. Rep. Ger.)  V.25-    1974- Volume(issue)/page/year:
   45,261,1994
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   TMPRAD Tropenmedizin und Parasitologie.  (Georg Thieme Verlag, Postfach 732,
   D-7000 Stuttgart 1, Fed. Rep. Ger.)  V.25-    1974- Volume(issue)/page/year:
   45,261,1994
 
                            *** END OF RECORD ***