*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : JH1940000
CHEMICAL NAME           : m-Dioxane-5-methanol,
                          2-furyl-5-(4,6-diaziridinyl-2-s-triazinylamino)-
CAS REGISTRY NUMBER     : 72239-53-3
LAST UPDATED            : 199801
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C16-H20-N6-O4
MOLECULAR WEIGHT        : 360.42
WISWESSER LINE NOTATION : T6O COTJ E1Q B- BT5OJ& EM- BT6N CN ENJ D- AT3NTJ& F-
                          AT3NTJ
SYNONYMS/TRADE NAMES :
   * 5-(4,6-Diaziridinyl-2-s-triazinylamino)-2-furyl-m-dioxane-5-methanol
   * 1,3-Dioxane-5-methanol,  
   5-((4,6-bis(1-aziridinyl)-1,3,5-triazin-2-yl)amino)-2-(2-furanyl)-
   * Furisyl
   * s-Triazine,  
   4,6-diaziridinyl-2-(2-furyl-5-hydroxymethyl-m-dioxan-5-ylamino)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6992 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JSONDX Journal of Soviet Oncology.  (New York, NY)  V.1-5, 1980-84.
   Volume(issue)/page/year: 1,239,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2992 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KHFZAN Khimiko-Farmatsevticheskii Zhurnal.  Chemical Pharmaceutical Journal.
    For English translation, see PCJOAU.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR)  V.1-    1967-  Volume(issue)/page/year: 12(4),67,1978
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg/10D-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   VOONAW Voprosy Onkologii.  Problems of Oncology.  For English translation,
   see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-10,
   1928-37; V.1-    1955-  Volume(issue)/page/year: 31(5),52,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 7 mg/kg/7D-I
TOXIC EFFECTS :
   Blood - thrombocytopenia
   Blood - changes in leukocyte (WBC) count
   Related to Chronic Data - death
REFERENCE :
   VOONAW Voprosy Onkologii.  Problems of Oncology.  For English translation,
   see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-10,
   1928-37; V.1-    1955-  Volume(issue)/page/year: 31(5),52,1985
 
                            *** END OF RECORD ***