*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : JI0400000
CHEMICAL NAME : 1,3-Dioxolane-4-methanol, 2,2-dimethyl-
CAS REGISTRY NUMBER : 100-79-8
BEILSTEIN REFERENCE NO. : 0104465
REFERENCE : 5-19-02-00362 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C6-H12-O3
MOLECULAR WEIGHT : 132.18
WISWESSER LINE NOTATION : T5O COTJ B1 B1 D1Q
COMPOUND DESCRIPTOR : Drug
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acetone, cyclic (hydroxymethyl)ethylene acetal
* Acetone glycerol
* 2,2-Dimethyl-1,3-dioxolane-4-methanol
* 2,2-Dimethyl-5-hydroxymethyl-1,3-dioxolane
* 2,2-Dimethyl-4-oxymethyl-1,3-dioxolane
* Dioxolan
* GIE
* Glycerolacetone
* Glycerol dimethylketal
* Glycerol, 1,2-O-isopropylidene
* 4-Hydroxymethyl-2,2-dimethyl-1,3-dioxolane
* Isopropylidene glycerol
* Solketal
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
39,129,1977
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
11,820,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
11,820,1989
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3740 ug/kg
TOXIC EFFECTS :
Cardiac - change in rate
Vascular - BP elevation not characterized in autonomic section
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
DECRDP Drugs under Experimental and Clinical Research. (Bioscience
Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977-
Volume(issue)/page/year: 9,895,1983
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 8530 ug/kg
TOXIC EFFECTS :
Cardiac - change in rate
Vascular - BP elevation not characterized in autonomic section
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
DECRDP Drugs under Experimental and Clinical Research. (Bioscience
Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977-
Volume(issue)/page/year: 9,895,1983
** MUTATION DATA **
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 1500 mg/kg
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 21,349,1984
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***