*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : JW4793000
CHEMICAL NAME           : Eburnamenine-14-carboxylic acid, methyl ester,
                          (3-alpha,16-alpha)-
CAS REGISTRY NUMBER     : 4880-92-6
LAST UPDATED            : 199806
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C21-H24-N2-O2
MOLECULAR WEIGHT        : 336.47
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Apovincamine
   * cis-Apovincamine
   * (+)-Apovincamine
   * (+)-cis-Apovincamine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRXXBL French Demande Patent Document.  (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #2319362
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4140777
 
                            *** END OF RECORD ***