*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KB4740000
CHEMICAL NAME           : 3,11a-Epidithio-11aH-pyrazino(1',2':1,5)pyrrolo(2,3-b
                          )indole-1,4-dione, 9-chloro-2,3,5a,6,
                          10b,11-hexahydro-10b,11-dihydroxy-7,8-dimethoxy-2,3,6
                          -trimethyl-, (3-alpha,5a-alpha,10b-
                          alpha,11-beta,11a-alpha)-
CAS REGISTRY NUMBER     : 1456-55-9
OTHER CAS REGISTRY NOS. : 1378-20-7
LAST UPDATED            : 199312
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C18-H20-Cl-N3-O6-S2
MOLECULAR WEIGHT        : 473.98
WISWESSER LINE NOTATION : T F6 E5 C566 A B 1C R ASSX LN NNV QNV PH&TT&&J DQ EQ
                          HG IO1 JO1 L1 P1 Q1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Hydroxysporidesmin B
   * Sporidesmin
   * Sporidesmin A
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 4(1),175,1980
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - domestic
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RVTSA9 Research in Veterinary Science.  (British Veterinary Assoc., 7
   Mansfield St., London W1M OAT, UK)  V.1-    1960-  Volume(issue)/page/year:
   11,183,1970
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 60 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 302,71,1993
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Cells - not otherwise specified
DOSE/DURATION           : 3 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 268,199,1992
 
                            *** END OF RECORD ***