*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KC9850000
CHEMICAL NAME           : 4,7-Epoxy-1H-isoindole-1,3(2H)-dione,
                          hexahydro-2-hydroxy-3a,7a-dimethyl-,
                          (3a-alpha,4-beta, 7-beta,7a-alpha)-
CAS REGISTRY NUMBER     : 76057-97-1
BEILSTEIN REFERENCE NO. : 0221648
REFERENCE               : 2-27-00-00298 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C10-H13-N-O4
MOLECULAR WEIGHT        : 211.24
WISWESSER LINE NOTATION : T C555 A AO DVNVTJ C1 EQ G1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * N-Hydroxycantharidinimide
   * N-Hydroxy-2,3-dimethyl-7-oxabicyclo(2.2.1)heptane-2,3-dicarboimide
   * 7-Oxabicyclo(2.2.1)heptane-2,3-dicarboximide, 2,3-dimethyl-N-hydroxy-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1040 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CHHTAT Zhonghua Yixue Zazhi.  Chinese Medical Journal.  (China International
   Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-    1915-   
   Suspended 1967-72.  Volume(issue)/page/year: 60,410,1980
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5510 mg/kg/40D-I
TOXIC EFFECTS :
   Gastrointestinal - alteration in gastric secretion
   Liver - change in gall bladder structure or function
   Kidney, Ureter, Bladder - hematuria
REFERENCE :
   CHHTAT Zhonghua Yixue Zazhi.  Chinese Medical Journal.  (China International
   Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-    1915-   
   Suspended 1967-72.  Volume(issue)/page/year: 60,410,1980
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1080 mg/kg/15D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder
   Nutritional and Gross Metabolic - changes in calcium
REFERENCE :
   CHHTAT Zhonghua Yixue Zazhi.  Chinese Medical Journal.  (China International
   Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-    1915-   
   Suspended 1967-72.  Volume(issue)/page/year: 60,410,1980
 
                            *** END OF RECORD ***