*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : KD1923000 CHEMICAL NAME : 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) furan-1,11(2H)-dione, 5,6,9,17,19,21- hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl -8-(N-1-piperazinylfo rmimidoyl)-, 21- acetate CAS REGISTRY NUMBER : 13292-45-0 BEILSTEIN REFERENCE NO. : 0603769 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C42-H56-N4-O12 MOLECULAR WEIGHT : 809.02 COMPOUND DESCRIPTOR : Drug Mutagen SYNONYMS/TRADE NAMES : * AF/AP * Demethylrifampicin * N-Demethyl-rifampicin * 4-N-Demethylrifampicin * N-Demethylrifampin * 3-((1-Piperazinylimino)methyl)rifampicin * Rifampicin AF/AP * Rifampicin, 3-((1-piperazinylimino)methyl)- *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,531,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 695 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CMTRAG Chemotherapia. (Basel, Switzerland) V.1-12, 1960-67. For publisher information, see CHTHBK. Volume(issue)/page/year: 12,155,1967 ** MUTATION DATA ** TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 100 mg/L REFERENCE : BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 60,96,1974 *** END OF RECORD ***