*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KD9999900
CHEMICAL NAME           : Eremomycin
CAS REGISTRY NUMBER     : 110865-90-2
LAST UPDATED            : 199403
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C73-H89-Cl-N10-O26
MOLECULAR WEIGHT        : 1558.17
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * A 82846A
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - necrotic changes
   Skin and Appendages - hair
REFERENCE :
   ANKHEW Antibiotiki i Khimioterapiya.  Antibiotics and Chemotherapy. (V/O Me
   zhdunarodnaya Kniga, 113095 Moskow, USSR)  V.33-    1988-
   Volume(issue)/page/year: 34,209,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - ulceration or bleeding from stomach
   Skin and Appendages - hair
REFERENCE :
   ANKHEW Antibiotiki i Khimioterapiya.  Antibiotics and Chemotherapy. (V/O Me
   zhdunarodnaya Kniga, 113095 Moskow, USSR)  V.33-    1988-
   Volume(issue)/page/year: 34,209,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1700 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - ulceration or bleeding from stomach
   Skin and Appendages - hair
REFERENCE :
   ANKHEW Antibiotiki i Khimioterapiya.  Antibiotics and Chemotherapy. (V/O Me
   zhdunarodnaya Kniga, 113095 Moskow, USSR)  V.33-    1988-
   Volume(issue)/page/year: 34,209,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1760 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya.  Antibiotics and Medical
   Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.30-V.32,
   1985-1987  Volume(issue)/page/year: 32,571,1987
 
                            *** END OF RECORD ***