*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KE1860000
CHEMICAL NAME           : Ergoline-8-acetamide, 6-methyl-, (8-beta)-,
                          (R-(R*,R*))-2,3-dihydroxybutanedioate (1:2)
CAS REGISTRY NUMBER     : 41562-69-0
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C17-H21-N3-O.2C4-H6-O6
MOLECULAR WEIGHT        : 583.61
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Deprenon
   * (8-beta)-6-Methylergoline-8-acetamide ditartrate
   * D-6-Methyl-8-ergolin-1-yl-essigsaeureamidtartrat
   * VUFB-6683
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 600 ug/kg
SEX/DURATION            : lactating female 4 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Maternal Effects - postpartum
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 23,617,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 300 ug/kg
SEX/DURATION            : female 5 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 44,3385,1979
 
                            *** END OF RECORD ***